PF21123

Dna2 Rift barrel domain

Pfam entry
Member databasePfam
Pfam typedomain
Short nameDna2_Rift
ClanALR_C-like
Author Bateman A;0000-0002-6982-4660
Sequence Ontology0000417

Description

This entry represents a Rift barrel domain found in the Dna2 protein
[1]
. This domain lies between the nuclease and helicase domains
[1]
. The Dna2 nuclease-helicase maintains genomic integrity by processing DNA double-strand breaks, Okazaki fragments and stalled replication forks. Dna2 requires ssDNA ends, and is dependent on the ssDNA-binding protein Rpa, which controls cleavage polarity.

References

1.Dna2 nuclease-helicase structure, mechanism and regulation by Rpa. Zhou C, Pourmal S, Pavletich NP. Elife 4, e09832, (2015). PMID: 26491943

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