Member database | Pfam |
Pfam type | domain |
Short name | Dna2_Rift |
Clan | ALR_C-like |
Author | Bateman A;0000-0002-6982-4660 |
Sequence Ontology | 0000417 |
Description
This entry represents a Rift barrel domain found in the Dna2 protein
[1]. This domain lies between the nuclease and helicase domains
[1]. The Dna2 nuclease-helicase maintains genomic integrity by processing DNA double-strand breaks, Okazaki fragments and stalled replication forks. Dna2 requires ssDNA ends, and is dependent on the ssDNA-binding protein Rpa, which controls cleavage polarity.