PF21126

Katanin p60 subunit A1, MIT domain

Pfam entry
Member databasePfam
Pfam typedomain
Short nameKATNA1_MIT
ClanMIT
Author Bateman A;0000-0002-6982-4660 Chuguransky S;0000-0002-0520-0736
Sequence Ontology0000417

Description

Katanin is an ATP-dependent microtubule severing protein composed of 60kDa (katanin-p60) and 80kDa (katanin-p80) subunits (KATNA1 and KATNB1, respectively) [1-4]. In mammals, there are two additional A-like subunits (KATNAL1 and KATNAL2) and one additional B-like subunit (KATNBL1)
[1]
. KATNA1 has the enzymatic activity for microtubule severing and plays a key role in cytoskeletal reorganisation, while KATNB is the regulatory subunit. Formation of the katanin A/B heterodimer is mediated by the N-terminal Microtubule Interacting and Trafficking domain (MIT, represented in this entry) of KATNA1/KATNAL1) and a conserved C-terminal domain of KATNB
[2]
. This domain is organised in an antiparallel three-helix bundle
[3]
.

References

1.Proteomic Analysis of the Mammalian Katanin Family of Microtubule-severing Enzymes Defines Katanin p80 subunit B-like 1 (KATNBL1) as a Regulator of Mammalian Katanin Microtubule-severing. Cheung K, Senese S, Kuang J, Bui N, Ongpipattanakul C, Gholkar A, Cohn W, Capri J, Whitelegge JP, Torres JZ. Mol. Cell Proteomics 15, 1658-69, (2016). PMID: 26929214

2.Microtubule minus-end regulation at spindle poles by an ASPM-katanin complex. Jiang K, Rezabkova L, Hua S, Liu Q, Capitani G, Altelaar AFM, Heck AJR, Kammerer RA, Steinmetz MO, Akhmanova A. Nat Cell Biol 19, 480-492, (2017). PMID: 28436967

3.A common substrate recognition mode conserved between katanin p60 and VPS4 governs microtubule severing and membrane skeleton reorganization. Iwaya N, Kuwahara Y, Fujiwara Y, Goda N, Tenno T, Akiyama K, Mase S, Tochio H, Ikegami T, Shirakawa M, Hiroaki H. J. Biol. Chem. 285, 16822-9, (2010). View articlePMID: 20339000

Further reading

4. Katanin-p80 gene promoter characterization and regulation via Elk1. Selcuk E, Kırımtay K, Canbaz D, Cesur GI, Korulu S, Karabay A. PLoS ONE 8, e69423, (2013). View articlePMID: 23894477

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