PF21127

ATG1-like, MIT domain 2

Pfam entry
Member databasePfam
Pfam typedomain
Short nameATG1-like_MIT2
ClanMIT
Author Assefa S;0000-0003-2178-533X Coggill P;0000-0001-5731-1588 Bateman A;0000-0002-6982-4660 Chuguransky S;0000-0002-0520-0736
Sequence Ontology0000417

Description

Members of this entry are serine/threonine-protein kinases and includes Atg1 from yeasts, Unc-51 from C. elegans and ULK1-2 from humans. Atg1 is required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway
[2, 3]
. Unc-51 is important for axonal elongation and axonal guidance
[1]
and ULK1-2 are involved in autophagy in response to starvation
[4]
. They consist of a kinase domain at the N-terminal (Pfam:PF00069) and two tandem microtubule interacting and transport (MIT) domains (tMIT) at the C-terminal which, in ATG1, mediates the interaction with ATG13
[2]
. In ULK1-2, MIT domain control the regulatory function and localization of the proteins and also mediate interactions with additional autophagy proteins
[4]
. This is the C-terminal MIT domain (MIT2).

References

1.The autophagy-related kinase UNC-51 and its binding partner UNC-14 regulate the subcellular localization of the Netrin receptor UNC-5 in Caenorhabditis elegans. Ogura K, Goshima Y. Development 133, 3441-50, (2006). View articlePMID: 16887826

2.Structural basis of starvation-induced assembly of the autophagy initiation complex. Fujioka Y, Suzuki SW, Yamamoto H, Kondo-Kakuta C, Kimura Y, Hirano H, Akada R, Inagaki F, Ohsumi Y, Noda NN. Nat Struct Mol Biol 21, 513-21, (2014). PMID: 24793651

3.ATG genes involved in non-selective autophagy are conserved from yeast to man, but the selective Cvt and pexophagy pathways also require organism-specific genes. Meijer WH, van der Klei IJ, Veenhuis M, Kiel JA. Autophagy 3, 106-16, (2007). PMID: 17204848

4.Kinase-inactivated ULK proteins inhibit autophagy via their conserved C-terminal domains using an Atg13-independent mechanism. Chan EY, Longatti A, McKnight NC, Tooze SA. Mol Cell Biol 29, 157-71, (2009). PMID: 18936157

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