PF21196

PcrA/UvrD tudor domain

Pfam entry
Member databasePfam
Pfam typedomain
Short namePcrA_UvrD_tudor
ClanSH3
Author Bateman A;0000-0002-6982-4660
Sequence Ontology0000417

Description

The PcrA/UvrD helicase binds directly to RNA polymerase (RNAP). This entry represents the C-terminal tudor domain that mediates interaction with RNA polymerase [1-5].

References

1. Crystal structure of a DExx box DNA helicase. Subramanya HS, Bird LE, Brannigan JA, Wigley DB. Nature 384, 379-83, (1996). View articlePMID: 8934527

2. The structure and function of an RNA polymerase interaction domain in the PcrA/UvrD helicase. Sanders K, Lin CL, Smith AJ, Cronin N, Fisher G, Eftychidis V, McGlynn P, Savery NJ, Wigley DB, Dillingham MS. Nucleic Acids Res 45, 3875-3887, (2017). View articlePMID: 28160601

3. Structural and mechanistic insight into DNA unwinding by Deinococcus radiodurans UvrD. Stelter M, Acajjaoui S, McSweeney S, Timmins J. PLoS One 8, e77364, (2013). View articlePMID: 24143224

4. UvrD helicase-RNA polymerase interactions are governed by UvrD's carboxy-terminal Tudor domain. Kawale AA, Burmann BM. Commun Biol 3, 607, (2020). View articlePMID: 33097771

5. DNA binding mediates conformational changes and metal ion coordination in the active site of PcrA helicase. Soultanas P, Dillingham MS, Velankar SS, Wigley DB. J. Mol. Biol. 290, 137-48, (1999). View articlePMID: 10388562

This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our Privacy Notice and Terms of Use.