PF21218

Formamidopyrimidine-DNA glycosylase-like, C-terminal domain

Pfam entry
Member databasePfam
Pfam typedomain
Short nameFpg-like_C
Author Bateman A;0000-0002-6982-4660 Lazaro Pinto Beatriz;0000-0001-6837-2941
Sequence Ontology0000417

Description

This domain is found in Formamidopyrimidine-DNA glycosylase-like from Arabidopsis thaliana (Fpg) and similar proteins from plants. Fpg is involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. It catalyses the hydrolysis of the N-glycosylic bond between the damaged base and the deoxyribose (glycosylase activity) before cleaving the DNA backbone (lyase activity). This entry represents the C-terminal domain, which shows four alpha- helices, two of them forming the helix-two-turn-helix (H2TH) motif, and two antiparallel beta-strands involved in a structural motif mimicking an antiparallel beta-hairpin zinc finger
[1]
.

References

1.Structural and biochemical studies of a plant formamidopyrimidine-DNA glycosylase reveal why eukaryotic Fpg glycosylases do not excise 8-oxoguanine. Duclos S, Aller P, Jaruga P, Dizdaroglu M, Wallace SS, Doublie S. DNA Repair (Amst.) 11, 714-25, (2012). View articlePMID: 22789755

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