PF21222

Lysosome-associated membrane glycoprotein 2, transmembrane segment

Pfam entry
Member databasePfam
Pfam typedomain
Short nameLamp2_2nd
Author Bateman A;0000-0002-6982-4660 Lazaro Pinto Beatriz;0000-0001-6837-2941
Sequence Ontology0000417

Description

This domain is found in Lysosome-associated membrane glycoprotein 2 from humans (Lamp2) and similar proteins from vertebrates. Lamp2 is an integral membrane protein that plays an important role in chaperone-mediated autophagy (CMA), targeting pertinent proteins for lysosomal degradation. This protein is organised into two conserved luminal domains, a single transmembrane domain (this entry) and a short C-terminal cytosolic tail. It adopts a trimeric configuration, and the transmembrane domains of the three monomers form a three-helix bundle structure
[1]
.

References

1.Structure of transmembrane domain of lysosome-associated membrane protein type 2a (LAMP-2A) reveals key features for substrate specificity in chaperone-mediated autophagy. Rout AK, Strub MP, Piszczek G, Tjandra N. J Biol Chem 289, 35111-23, (2014). PMID: 25342746

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