Member database | Pfam |
Pfam type | domain |
Short name | Lamp2_2nd |
Author | Bateman A;0000-0002-6982-4660 Lazaro Pinto Beatriz;0000-0001-6837-2941 |
Sequence Ontology | 0000417 |
Description
This domain is found in Lysosome-associated membrane glycoprotein 2 from humans (Lamp2) and similar proteins from vertebrates. Lamp2 is an integral membrane protein that plays an important role in chaperone-mediated autophagy (CMA), targeting pertinent proteins for lysosomal degradation. This protein is organised into two conserved luminal domains, a single transmembrane domain (this entry) and a short C-terminal cytosolic tail. It adopts a trimeric configuration, and the transmembrane domains of the three monomers form a three-helix bundle structure
[1].