PF21447

Ppx/GppA phosphatase, domain III

Pfam entry
Member databasePfam
Pfam typedomain
Short namePpx-GppA_III
ClanHD_PDEase
Author Bateman A;0000-0002-6982-4660 Chuguransky S;0000-0002-0520-0736
Sequence Ontology0000417

Description

Ppx/GppA phosphatases belong to ASKHA (acetate and sugar kinases, Hsp70, actin) which has an N-terminal (Pfam:PF02541) nucleotide-binding domain (domains I/II), domain III which corresponds to the catalytic phosphohydrolase domain with the common helical fold and domain IV [1-3]. This entry represents domain III.

References

1. The structure of the exopolyphosphatase (PPX) from Escherichia coli O157:H7 suggests a binding mode for long polyphosphate chains. Rangarajan ES, Nadeau G, Li Y, Wagner J, Hung MN, Schrag JD, Cygler M, Matte A. J. Mol. Biol. 359, 1249-60, (2006). View articlePMID: 16678853

2. Origin of exopolyphosphatase processivity: Fusion of an ASKHA phosphotransferase and a cyclic nucleotide phosphodiesterase homolog. Alvarado J, Ghosh A, Janovitz T, Jauregui A, Hasson MS, Sanders DA. Structure 14, 1263-72, (2006). View articlePMID: 16905100

3. Structure and activity of PPX/GppA homologs from Escherichia coli and Helicobacter pylori. Song H, Dharmasena MN, Wang C, Shaw GX, Cherry S, Tropea JE, Jin DJ, Ji X. FEBS J 287, 1865-1885, (2020). View articlePMID: 31679177

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