Member database | Pfam |
Pfam type | domain |
Short name | HL_N-beta |
Clan | E-set |
Author | Bateman A;0000-0002-6982-4660 Chuguransky S;0000-0002-0520-0736 |
Sequence Ontology | 0000417 |
Description
Hyaluronate lyase degrades hyaluronan and certain chondroitin sulfates at beta-1,4 glycosidic linkages and constitutes a virulence factor of Streptococcus agalactiae
[1]. It consists of three structural domains, an N-terminal beta-sheet domain (also referred as to beta1), a middle catalytic alpha-helical domain (Pfam:PF08124) and a C-terminal beta-sheet domain (beta2, Pfam:PF02278)
[1]. This entry represents the N-terminal beta-sheet domain which adopts a Ig-like fold and may serve as a connection of the alpha-domain with another structural domain
[1].
References
1.Hyaluronan binding and degradation by Streptococcus agalactiae hyaluronate lyase. Li S, Jedrzejas MJ. J. Biol. Chem. 276, 41407-16, (2001). View articlePMID: 11527972