PF21461

Hyaluronate lyase, N-terminal beta-sheet domain

Pfam entry
Member databasePfam
Pfam typedomain
Short nameHL_N-beta
ClanE-set
Author Bateman A;0000-0002-6982-4660 Chuguransky S;0000-0002-0520-0736
Sequence Ontology0000417

Description

Hyaluronate lyase degrades hyaluronan and certain chondroitin sulfates at beta-1,4 glycosidic linkages and constitutes a virulence factor of Streptococcus agalactiae
[1]
. It consists of three structural domains, an N-terminal beta-sheet domain (also referred as to beta1), a middle catalytic alpha-helical domain (Pfam:PF08124) and a C-terminal beta-sheet domain (beta2, Pfam:PF02278)
[1]
. This entry represents the N-terminal beta-sheet domain which adopts a Ig-like fold and may serve as a connection of the alpha-domain with another structural domain
[1]
.

References

1.Hyaluronan binding and degradation by Streptococcus agalactiae hyaluronate lyase. Li S, Jedrzejas MJ. J. Biol. Chem. 276, 41407-16, (2001). View articlePMID: 11527972

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