PF21547

TELO2-interacting protein 1

Pfam entry
Member databasePfam
Pfam typerepeat
Short nameTTI1
ClanTPR
Author Chuguransky S;0000-0002-0520-0736
Sequence Ontology0001068

Description

This entry includes TELO2-interacting protein 1 from yeast and its homologues from mammals. Budding yeast Tti1 is a subunit of the ASTRA complex, which is involved in chromatin remodelling
[2]
. Human TTI1 is a regulator of the DNA damage response (DDR). It is part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses
[3, 1]
. Together with the TTT complex and HSP90, participates in the proper folding of newly synthesized PIKKs
[1]
. Members of this entry are entirely composed of HEAT repeats
[3]
.

References

1.Tti1 and Tel2 are critical factors in mammalian target of rapamycin complex assembly. Kaizuka T, Hara T, Oshiro N, Kikkawa U, Yonezawa K, Takehana K, Iemura S, Natsume T, Mizushima N. J Biol Chem 285, 20109-16, (2010). PMID: 20427287

2.Chromatin Central: towards the comparative proteome by accurate mapping of the yeast proteomic environment. Shevchenko A, Roguev A, Schaft D, Buchanan L, Habermann B, Sakalar C, Thomas H, Krogan NJ, Shevchenko A, Stewart AF. Genome Biol. 9, R167, (2008). View articlePMID: 19040720

3.Structure of the TELO2-TTI1-TTI2 complex and its function in TOR recruitment to the R2TP chaperone. Pal M, Munoz-Hernandez H, Bjorklund D, Zhou L, Degliesposti G, Skehel JM, Hesketh EL, Thompson RF, Pearl LH, Llorca O, Prodromou C. Cell Rep 36, 109317, (2021). PMID: 34233195

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