PF22254

Tfa2 E-tether

Pfam entry
Member databasePfam
Pfam typedomain
Short nameTFA2_E-tether
Author Bateman A;0000-0002-6982-4660
Sequence Ontology0000417

Description

The small TFIIE subunit Tfa2 (human TFIIEbeta) contains two WH domains and two conserved alpha-helices called the E-tether
[1]
that bind the E-linker. Consistent with the structure, the E-tether is essential for TFIIE function and subunit dimerization.

References

1.Transcription initiation complex structures elucidate DNA opening. Plaschka C, Hantsche M, Dienemann C, Burzinski C, Plitzko J, Cramer P. Nature 533, 353-8, (2016). View articlePMID: 27193681

Further reading

2. Structures of transcription pre-initiation complex with TFIIH and Mediator. Schilbach S, Hantsche M, Tegunov D, Dienemann C, Wigge C, Urlaub H, Cramer P. Nature 551, 204-209, (2017). View articlePMID: 29088706

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