Member database | Pfam |
Pfam type | domain |
Short name | TFA2_E-tether |
Author | Bateman A;0000-0002-6982-4660 Lazaro Pinto Beatriz;0000-0001-6837-2941 |
Sequence Ontology | 0000417 |
Description
The small TFIIE subunit Tfa2 (yeast TFIIE-beta) contains two WH domains and two conserved alpha-helices called the E-tether
[1] that bind the E-linker. Consistent with the structure, the E-tether is essential for TFIIE function and subunit dimerisation. Members of this group are found in fungi.
References
1.Transcription initiation complex structures elucidate DNA opening. Plaschka C, Hantsche M, Dienemann C, Burzinski C, Plitzko J, Cramer P. Nature 533, 353-8, (2016). View articlePMID: 27193681
Further reading
2. Structures of transcription pre-initiation complex with TFIIH and Mediator. Schilbach S, Hantsche M, Tegunov D, Dienemann C, Wigge C, Urlaub H, Cramer P. Nature 551, 204-209, (2017). View articlePMID: 29088706