PF23283

Uromodulin-like, D8C domain

Pfam entry
Member databasePfam
Pfam typedomain
Short nameD8C_UMOD
Author Bateman A;0000-0002-6982-4660 Lazaro Pinto Beatriz;0000-0001-6837-2941
Sequence Ontology0000417

Description

This domain, described as D8C domain (cysteine-rich domain), is found in human Uromodulin (UMOD) and similar animal proteins. UMOD functions in biogenesis and organization of the apical membrane of epithelial cells of the thick ascending limb of Henle's loop and may serve as a receptor for binding and endocytosis of cytokines (IL-1, IL-2) and TNF. This domain adopts a predominantly beta structure
[1]
.

References

1.Structure of the decoy module of human glycoprotein 2 and uromodulin and its interaction with bacterial adhesin FimH. Stsiapanava A, Xu C, Nishio S, Han L, Yamakawa N, Carroni M, Tunyasuvunakool K, Jumper J, de Sanctis D, Wu B, Jovine L. Nat Struct Mol Biol 29, 190-193, (2022). View articlePMID: 35273390

Further reading

2. The cryo-EM structure of the human uromodulin filament core reveals a unique assembly mechanism. Stanisich JJ, Zyla DS, Afanasyev P, Xu J, Kipp A, Olinger E, Devuyst O, Pilhofer M, Boehringer D, Glockshuber R. Elife 9, e60265, (2020). View articlePMID: 32815518

3. Cryo-EM structure of native human uromodulin, a zona pellucida module polymer. Stsiapanava A, Xu C, Brunati M, Zamora-Caballero S, Schaeffer C, Bokhove M, Han L, Hebert H, Carroni M, Yasumasu S, Rampoldi L, Wu B, Jovine L. EMBO J 39, e106807, (2020). View articlePMID: 33196145

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