PF24311

THSD1 third Ig-like domain

Pfam entry
Member databasePfam
Pfam typedomain
Short nameTHSD1_D3
ClanE-set
Author Andreeva A;0000-0002-0450-0091
Sequence Ontology0000417

Description

This domain is found in the human Thrombospondin type-1 domain-containing protein 1 (THSD1) and related proteins. THSD1 is involved in endothelial cell to extracellular matrix adhesion
[1]
. THSD1 forms a multimeric protein complex with FAK/talin/ vinculin, wherein THSD1 promotes talin binding to FAK but not to vinculin, a key step in nascent adhesion assembly
[2]
. The domain represented by this entry is predicted to adopt Ig-like beta-sandwich.

References

1.THSD1 (Thrombospondin Type 1 Domain Containing Protein 1) Mutation in the Pathogenesis of Intracranial Aneurysm and Subarachnoid Hemorrhage. Santiago-Sim T, Fang X, Hennessy ML, Nalbach SV, DePalma SR, Lee MS, Greenway SC, McDonough B, Hergenroeder GW, Patek KJ, Colosimo SM, Qualmann KJ, Hagan JP, Milewicz DM, MacRae CA, Dymecki SM, Seidman CE, Seidman JG, Kim DH. Stroke 47, 3005-3013, (2016). View articlePMID: 27895300

2.The Intracranial Aneurysm Gene THSD1 Connects Endosome Dynamics to Nascent Focal Adhesion Assembly. Rui YN, Xu Z, Fang X, Menezes MR, Balzeau J, Niu A, Hagan JP, Kim DH. Cell Physiol Biochem 43, 2200-2211, (2017). View articlePMID: 29069646

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