PF24656

CEP76 peptidase-like domain

Pfam entry
Member databasePfam
Pfam typedomain
Short nameCEPT76_peptidase
ClanPeptidase_CA
Author Bateman A;0000-0002-6982-4660 Chuguransky S;0000-0002-0520-0736
Sequence Ontology0000417

Description

This entry represents a domain found in the middle of centrosomal protein of 76 kDa, a protein involved in regulation of centriole duplication to limit centriole duplication to once per cell cycle by preventing centriole reduplication
[1]
. This domain is also found at the C-terminal of C2D2A/B, whose function is unknown, and in dynein regulatory complex subunit 7 (DRC7). In DRC7, this model covers the C-terminal part of the domain as it has an insertion not present in the other members of the entry. This domain is may adopt a fold related to peptidases.

References

1.Cep76, a centrosomal protein that specifically restrains centriole reduplication. Tsang WY, Spektor A, Vijayakumar S, Bista BR, Li J, Sanchez I, Duensing S, Dynlacht BD. Dev. Cell 16, 649-60, (2009). View articlePMID: 19460342

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