PIRSF004848

Predicted pyridoxal 5'-phosphate-dependent enzyme, YBL036c type

PIRSF entry
Member databasePIRSF
PIRSF typefamily
Short nameYBL036c_PLPDEIII

Description

The prototype of this group, yeast hypothetical protein YBL036c, is homologous to a Pseudomonas aeruginosa gene that is co-transcribed with a known proline biosynthetic gene
[3]
. These proteins are classified as pyridoxal 5'-phosphate dependent enzymes class III
[2]
. Although widely distributed among all three kingdoms of life, they have not been characterised extensively.

For additional information please see
[4, 1]
.

References

1.The molecular evolution of pyridoxal-5'-phosphate-dependent enzymes. Mehta PK, Christen P. Adv. Enzymol. Relat. Areas Mol. Biol. 74, 129-84, (2000). PMID: 10800595

2.Structure of a yeast hypothetical protein selected by a structural genomics approach. Eswaramoorthy S, Gerchman S, Graziano V, Kycia H, Studier FW, Swaminathan S. Acta Crystallogr. D Biol. Crystallogr. 59, 127-35, (2003). PMID: 12499548

3.Cloning and characterization of human and mouse PROSC (proline synthetase co-transcribed) genes. Ikegawa S, Isomura M, Koshizuka Y, Nakamura Y. J. Hum. Genet. 44, 337-42, (1999). View articlePMID: 10496079

4.Common structural elements in the architecture of the cofactor-binding domains in unrelated families of pyridoxal phosphate-dependent enzymes. Denessiouk KA, Denesyuk AI, Lehtonen JV, Korpela T, Johnson MS. Proteins 35, 250-61, (1999). View articlePMID: 10223296

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