PR00051

DNAA

PRINTS entry
Member databasePRINTS
PRINTS typefamily
Short nameDNAA

Description
Imported from IPR020591

The bacterial DnaA protein
[1, 2, 3]
plays an important role in initiating and regulating chromosomal replication. DnaA is an ATP- and DNA-binding protein. It binds specifically to 9 bp nucleotide repeats known as dnaA boxes which are found in the chromosome origin of replication (oriC).

DnaA contains two conserved regions: the first is located in the N-terminal half and corresponds to the ATP-binding domain, the second is located in the C-terminal half and could be involved in DNA-binding. The protein may also bind the RNA polymerase beta subunit, the dnaB and dnaZ proteins, and the groE gene products (chaperonins)
[4]
.

This entry represents the chromosomal replication control initiator DnaA, as well as the DnaA homologue Hda, which is also involved in chromosomal replication control.

References
Imported from IPR020591

1.The initiator protein DnaA: evolution, properties and function. Skarstad K, Boye E. Biochim. Biophys. Acta 1217, 111-30, (1994). View articlePMID: 8110826

2.Structure and function of DnaA and the DnaA-box in eubacteria: evolutionary relationships of bacterial replication origins. Yoshikawa H, Ogasawara N. Mol. Microbiol. 5, 2589-97, (1991). View articlePMID: 1779750

3.The E. coli dnaA initiation protein: a protein for all seasons. Georgopoulos C. Trends Genet. 5, 319-21, (1989). View articlePMID: 2558436

4.Nucleotide sequence of a Proteus mirabilis DNA fragment homologous to the 60K-rnpA-rpmH-dnaA-dnaN-recF-gyrB region of Escherichia coli. Skovgaard O. Gene 93, 27-34, (1990). View articlePMID: 2172087

Supplementary References

1. Conserved gene arrangement in the origin region of the Streptomyces coelicolor chromosome. Calcutt MJ, Schmidt FJ. J. Bacteriol. 174, 3220-6, (1992). View articlePMID: 1577691

2. Pseudomonas chromosomal replication origins: a bacterial class distinct from Escherichia coli-type origins. Yee TW, Smith DW. Proc. Natl. Acad. Sci. U.S.A. 87, 1278-82, (1990). View articlePMID: 2106132

Integrated to
This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our Privacy Notice and Terms of Use.