PR00115

F16BPHPHTASE

PRINTS entry
Member databasePRINTS
PRINTS typefamily
Short nameF16BPHPHTASE

Description
Imported from IPR028343

Fructose bisphosphatase (FBPase)
3.1.3.11
is a critical regulatory enzyme in gluconeogenesis that catalyses the removal of 1-phosphate from fructose 1,6-bis-phosphate to form fructose 6-phosphate
[4, 1]
. It is involved in many different metabolic pathways and found in most organisms. FBPase requires metal ions for catalysis (Mg2+and Mn2+being preferred) and the enzyme is potently inhibited by Li+. The fold of fructose-1,6-bisphosphatase was noted to be identical to that of inositol-1-phosphatase (IMPase)
[3]
. Inositol polyphosphate 1-phosphatase (IPPase), IMPase and FBPase share a sequence motif (Asp-Pro-Ile/Leu-Asp-Gly/Ser-Thr/Ser) which has been shown to bind metal ions and participate in catalysis. This motif is also found in the distantly-related fungal, bacterial and yeast IMPase homologues. It has been suggested that these proteins define an ancient structurally conserved family involved in diverse metabolic pathways, including inositol signalling, gluconeogenesis, sulphate assimilation and possibly quinone metabolism
[2]
.

References
Imported from IPR028343

1.Amino acid sequence homology among fructose-1,6-bisphosphatases. Marcus F, Gontero B, Harrsch PB, Rittenhouse J. Biochem. Biophys. Res. Commun. 135, 374-81, (1986). View articlePMID: 3008716

2.Definition of a metal-dependent/Li(+)-inhibited phosphomonoesterase protein family based upon a conserved three-dimensional core structure. York JD, Ponder JW, Majerus PW. Proc. Natl. Acad. Sci. U.S.A. 92, 5149-53, (1995). View articlePMID: 7761465

3.Structural similarities between fructose-1,6-bisphosphatase and inositol monophosphatase. Zhang Y, Liang JY, Lipscomb WN. Biochem. Biophys. Res. Commun. 190, 1080-3, (1993). View articlePMID: 8382485

4.Amino acid sequence of spinach chloroplast fructose-1,6-bisphosphatase. Marcus F, Harrsch PB. Arch. Biochem. Biophys. 279, 151-7, (1990). View articlePMID: 2159755

Supplementary References

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