PR00234

HIV1MATRIX

PRINTS entry
Member databasePRINTS
PRINTS typefamily
Short nameHIV1MATRIX

Description
Imported from IPR000071

Retroviral matrix proteins (or major core proteins) are components of envelope-associated capsids, which line the inner surface of virus envelopes and are associated with viral membranes
[1]
. Matrix proteins are produced as part of Gag precursor polyproteins. During viral maturation, the Gag polyprotein is cleaved into major structural proteins by the viral protease, yielding the matrix (MA), capsid (CA), nucleocapsid (NC), and some smaller peptides. Gag-derived proteins govern the entire assembly and release of the virus particles, with matrix proteins playing key roles in Gag stability, capsid assembly, transport and budding. Although matrix proteins from different retroviruses appear to perform similar functions and can have similar structural folds which predominantly consist of four closely packed α-helices that are interconnected through loops, their primary sequences can be very different
[4]
.

This entry represents matrix proteins from immunodeficiency lentiviruses, such as Human immunodeficiency virus (HIV) and Simian immunodeficiency virus (SIV-cpz)
[2]
. The structure of the HIV protein consists of 5 α helices, a short 3.10 helix and a 3-stranded mixed β-sheet
[3]
.

References
Imported from IPR000071

1.Retroviral matrix proteins: a structural perspective. Conte MR, Matthews S. Virology 246, 191-8, (1998). View articlePMID: 9657938

2.HIV-1 replication. Freed EO. Somat. Cell Mol. Genet. 26, 13-33, (2001). View articlePMID: 12465460

3.Three-dimensional structure of the human immunodeficiency virus type 1 matrix protein. Massiah MA, Starich MR, Paschall C, Summers MF, Christensen AM, Sundquist WI. J. Mol. Biol. 244, 198-223, (1994). View articlePMID: 7966331

4.D-retrovirus morphogenetic switch driven by the targeting signal accessibility to Tctex-1 of dynein. Vlach J, Lipov J, Rumlova M, Veverka V, Lang J, Srb P, Knejzlik Z, Pichova I, Hunter E, Hrabal R, Ruml T. Proc. Natl. Acad. Sci. U.S.A. 105, 10565-70, (2008). View articlePMID: 18647839

Supplementary References

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