PR00431

INTERLEUKIN4

PRINTS entry
Member databasePRINTS
PRINTS typefamily
Short nameINTERLEUKIN4

Description
Imported from IPR002354

Cytokines are protein messengers that carry information from cell to cell
[1]
. Interleukin is one such molecule, and participates in several B-cell activation processes: e.g., it enhances production and secretion of IgG1 and IgE
[2]
; it induces expression of class II major histocompatability complex (MHC) molecules on resting B-cells; and it regulates expression of the low affinity Fc receptor for IgE on lymphocytes and monocytes. Interleukin-4 (IL4), which this entry represents, has a compact, globular fold (similar to other cytokines), stabilised by 3 disulphide bonds
[3]
. One half of the structure is dominated by a 4 α-helix bundle with a left-handed twist
[4]
. The helices are anti-parallel, with 2 overhand connections, which fall into a 2-stranded anti-parallel β-sheet
[4]
.

References
Imported from IPR002354

1.Aspects of receptor binding and signalling of interleukin-4 investigated by site-directed mutagenesis and NMR spectroscopy. Muller T, Dieckmann T, Sebald W, Oschkinat H. J. Mol. Biol. 237, 423-36, (1994). View articlePMID: 8151703

2.Isolation and characterization of a mouse interleukin cDNA clone that expresses B-cell stimulatory factor 1 activities and T-cell- and mast-cell-stimulating activities. Lee F, Yokota T, Otsuka T, Meyerson P, Villaret D, Coffman R, Mosmann T, Rennick D, Roehm N, Smith C. Proc. Natl. Acad. Sci. U.S.A. 83, 2061-5, (1986). View articlePMID: 3083412

3.Disulfide assignments in recombinant mouse and human interleukin 4. Carr C, Aykent S, Kimack NM, Levine AD. Biochemistry 30, 1515-23, (1991). View articlePMID: 1993171

4.Crystal structure of recombinant human interleukin-4. Walter MR, Cook WJ, Zhao BG, Cameron RP Jr, Ealick SE, Walter RL Jr, Reichert P, Nagabhushan TL, Trotta PP, Bugg CE. J. Biol. Chem. 267, 20371-6, (1992). View articlePMID: 1400355

Supplementary References

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