PR00662

G6PISOMERASE

PRINTS entry
Member databasePRINTS
PRINTS typefamily
Short nameG6PISOMERASE

Description
Imported from IPR001672

Phosphoglucose isomerase (
5.3.1.9
) (PGI)
[1, 2]
is a dimeric enzyme that catalyses the reversible isomerization of glucose-6-phosphate and fructose-6-phosphate. PGI is involved in different pathways: in most higher organisms it is involved in glycolysis; in mammals it is involved in gluconeogenesis; in plants in carbohydrate biosynthesis; in some bacteria it provides a gateway for fructose into the Entner-Doudouroff pathway. The multifunctional protein, PGI, is also known as neuroleukin (a neurotrophic factor that mediates the differentiation of neurons), autocrine motility factor (a tumour-secreted cytokine that regulates cell motility), differentiation and maturation mediator and myofibril-bound serine proteinase inhibitor, and has different roles inside and outside the cell. In the cytoplasm, it catalyses the second step in glycolysis, while outside the cell it serves as a nerve growth factor and cytokine
[3]
.

References
Imported from IPR001672

1.Glucose-6-phosphate isomerase. Achari A, Marshall SE, Muirhead H, Palmieri RH, Noltmann EA. Philos. Trans. R. Soc. Lond., B, Biol. Sci. 293, 145-57, (1981). View articlePMID: 6115414

2.Anomalous phylogeny involving the enzyme glucose-6-phosphate isomerase. Smith MW, Doolittle RF. J. Mol. Evol. 34, 544-5, (1992). View articlePMID: 1593646

3.Crystal structure of rabbit phosphoglucose isomerase, a glycolytic enzyme that moonlights as neuroleukin, autocrine motility factor, and differentiation mediator. Jeffery CJ, Bahnson BJ, Chien W, Ringe D, Petsko GA. Biochemistry 39, 955-64, (2000). View articlePMID: 10653639

Further reading

4. The crystal structure of a multifunctional protein: phosphoglucose isomerase/autocrine motility factor/neuroleukin. Sun YJ, Chou CC, Chen WS, Wu RT, Meng M, Hsiao CD. Proc. Natl. Acad. Sci. U.S.A. 96, 5412-7, (1999). View articlePMID: 10318897

5. The crystal structure of phosphoglucose isomerase/autocrine motility factor/neuroleukin complexed with its carbohydrate phosphate inhibitors suggests its substrate/receptor recognition. Chou CC, Sun YJ, Meng M, Hsiao CD. J. Biol. Chem. 275, 23154-60, (2000). View articlePMID: 10770936

Supplementary References

1. Mouse glucose-6-phosphate isomerase and neuroleukin have identical 3' sequences. Faik P, Walker JI, Redmill AA, Morgan MJ. Nature 332, 455-7, (1988). View articlePMID: 3352745

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