Member database | PRINTS |
PRINTS type | family |
Short name | CALPAIN |
Description Imported from IPR022684
- * A 19-amino acid NH2-terminal sequence;
* Active site domain IIa;
* Active site domain IIb. Domain 2 shows low levels of sequence similarity to papain; although the catalytic His has not been located by biochemical means, it is likely that calpain and papain are related
* Domain III;
* An 18-amino acid extended sequence linking domain III to domain IV;
* Domain IV, which resembles the penta EF-hand family of polypeptides, binds calcium and regulates activity
References Imported from IPR022684
1.How calpain is activated by calcium. Khorchid A, Ikura M. Nat. Struct. Biol. 9, 239-41, (2002). View articlePMID: 11914728
2.Tandemly reiterated negative enhancer-like elements regulate transcription of a human gene for the large subunit of calcium-dependent protease. Hata A, Ohno S, Akita Y, Suzuki K. J. Biol. Chem. 264, 6404-11, (1989). View articlePMID: 2539381
3.Calpains: an elaborate proteolytic system. Ono Y, Sorimachi H. Biochim. Biophys. Acta 1824, 224-36, (2012). View articlePMID: 21864727
4.The structure of calpain. Sorimachi H, Suzuki K. J. Biochem. 129, 653-64, (2001). View articlePMID: 11328585
5.Structural basis for possible calcium-induced activation mechanisms of calpains. Reverter D, Strobl S, Fernandez-Catalan C, Sorimachi H, Suzuki K, Bode W. Biol. Chem. 382, 753-66, (2001). View articlePMID: 11517928
6.Families of cysteine peptidases. Rawlings ND, Barrett AJ. Meth. Enzymol. 244, 461-86, (1994). View articlePMID: 7845226
7.The calpain system. Goll DE, Thompson VF, Li H, Wei W, Cong J. Physiol. Rev. 83, 731-801, (2003). View articlePMID: 12843408
8.Structure and physiological function of calpains. Sorimachi H, Ishiura S, Suzuki K. Biochem. J. 328 ( Pt 3), 721-32, (1997). View articlePMID: 9396712
9.Molecular cloning of a novel mammalian calcium-dependent protease distinct from both m- and mu-types. Specific expression of the mRNA in skeletal muscle. Sorimachi H, Imajoh-Ohmi S, Emori Y, Kawasaki H, Ohno S, Minami Y, Suzuki K. J. Biol. Chem. 264, 20106-11, (1989). View articlePMID: 2555341
10.Cutting to the chase: calpain proteases in cell motility. Glading A, Lauffenburger DA, Wells A. Trends Cell Biol. 12, 46-54, (2002). View articlePMID: 11854009
11.Calpain. Perrin BJ, Huttenlocher A. Int. J. Biochem. Cell Biol. 34, 722-5, (2002). View articlePMID: 11950589