PR00745

GLHYDRLASE39

PRINTS entry
Member databasePRINTS
PRINTS typefamily
Short nameGLHYDRLASE39

Description
Imported from IPR000514

Glycoside hydrolase family 39 (
GH39
) comprises enzymes with several known activities such as alpha-L-iduronidase (
3.2.1.76
), beta-xylosidase (
3.2.1.37
), and alpha-1,4-L-rhamnosidase
[3]
.

The most highly conserved regions in these enzymes are located in their N-terminal parts. These contain a glutamic acid residue which, on the basis of similarities with other families of glycosyl hydrolases
[2]
, probably acts as the proton donor in their catalytic mechanism.

O-Glycosyl hydrolases (
3.2.1.
) are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycosyl hydrolases, based on sequence similarity, has led to the definition of 85 different families
[2, 1]
. This classification is available on the CAZy (CArbohydrate-Active EnZymes) website.

References
Imported from IPR000514

1.Structures and mechanisms of glycosyl hydrolases. Davies G, Henrissat B. Structure 3, 853-9, (1995). View articlePMID: 8535779

2.Conserved catalytic machinery and the prediction of a common fold for several families of glycosyl hydrolases. Henrissat B, Callebaut I, Fabrega S, Lehn P, Mornon JP, Davies G. Proc. Natl. Acad. Sci. U.S.A. 92, 7090-4, (1995). View articlePMID: 7624375

3.A marine bacterial enzymatic cascade degrades the algal polysaccharide ulvan. Reisky L, Prechoux A, Zuhlke MK, Baumgen M, Robb CS, Gerlach N, Roret T, Stanetty C, Larocque R, Michel G, Song T, Markert S, Unfried F, Mihovilovic MD, Trautwein-Schult A, Becher D, Schweder T, Bornscheuer UT, Hehemann JH. Nat. Chem. Biol. 15, 803-812, (2019). PMID: 31285597

Supplementary References

1. Cloning and characterization of cDNA encoding canine alpha-L-iduronidase. mRNA deficiency in mucopolysaccharidosis I dog. Stoltzfus LJ, Sosa-Pineda B, Moskowitz SM, Menon KP, Dlott B, Hooper L, Teplow DB, Shull RM, Neufeld EF. J. Biol. Chem. 267, 6570-5, (1992). View articlePMID: 1551868

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