Member database | PRINTS |
PRINTS type | family |
Short name | NCTRNSLOCATR |
Description Imported from IPR001067
The Ah (dioxin) receptor nuclear translocator protein (Arnt) belongs to the basic helix-loop-helix (bHLH) family of transcription factors and is required for Ah receptor function. The Ah receptor binds, and mediates the carcinogenic effects of a variety of environmental pollutants, including 2,3,7,8-tetrachlorodibenzo-p-dioxin and polycyclic aromatic hydrocarbons. Arnt is a structural component of the XRE-binding form of the Ah receptor. These proteins are class VII members of the basic helix-loop-helix (bHLH) family. The bHLH domain may be responsible for interacting with both the XRE and the ligand-binding subunit
[1, 2].
The activated Ah receptor and Arnt protein bind DNA as a heterodimer. Both proteins contain PAS homology regions, which in Drosophila PER and SIM proteins function as dimerisation domains
[1].
References Imported from IPR001067
1.Identification of functional domains of the aryl hydrocarbon receptor nuclear translocator protein (ARNT). Reisz-Porszasz S, Probst MR, Fukunaga BN, Hankinson O. Mol. Cell. Biol. 14, 6075-86, (1994). View articlePMID: 8065341
2.Identification of the Ah receptor nuclear translocator protein (Arnt) as a component of the DNA binding form of the Ah receptor. Reyes H, Reisz-Porszasz S, Hankinson O. Science 256, 1193-5, (1992). View articlePMID: 1317062