PR00785

NCTRNSLOCATR

PRINTS entry
Member databasePRINTS
PRINTS typefamily
Short nameNCTRNSLOCATR

Description
Imported from IPR001067

The Ah (dioxin) receptor nuclear translocator protein (Arnt) belongs to the basic helix-loop-helix (bHLH) family of transcription factors and is required for Ah receptor function. The Ah receptor binds, and mediates the carcinogenic effects of a variety of environmental pollutants, including 2,3,7,8-tetrachlorodibenzo-p-dioxin and polycyclic aromatic hydrocarbons. Arnt is a structural component of the XRE-binding form of the Ah receptor. These proteins are class VII members of the basic helix-loop-helix (bHLH) family. The bHLH domain may be responsible for interacting with both the XRE and the ligand-binding subunit
[1, 2]
.

The activated Ah receptor and Arnt protein bind DNA as a heterodimer. Both proteins contain PAS homology regions, which in Drosophila PER and SIM proteins function as dimerisation domains
[1]
.

References
Imported from IPR001067

1.Identification of functional domains of the aryl hydrocarbon receptor nuclear translocator protein (ARNT). Reisz-Porszasz S, Probst MR, Fukunaga BN, Hankinson O. Mol. Cell. Biol. 14, 6075-86, (1994). View articlePMID: 8065341

2.Identification of the Ah receptor nuclear translocator protein (Arnt) as a component of the DNA binding form of the Ah receptor. Reyes H, Reisz-Porszasz S, Hankinson O. Science 256, 1193-5, (1992). View articlePMID: 1317062

Supplementary References

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