PR00913

LVIRUSORF2

PRINTS entry
Member databasePRINTS
PRINTS typefamily
Short nameLVIRUSORF2

Description
Imported from IPR018019

ORF2 of Potato leafroll virus (PLrV) encodes a polyprotein which is translated following a -1 frameshift. The polyprotein has a putative linear arrangement of membrane achor-VPg-peptidase-polmerase domains. The serine peptidase domain which is found in this group of sequences belongs to MEROPS peptidase family S39 (clan PA(S)), subfamily S39B. It is likely that the peptidase domain is involved in the cleavage of the polyprotein
[1]
.

The nucleotide sequence for the RNA of PLrV has been determined
[2, 3]
. The sequence contains six large open reading frames (ORFs). The 5' coding region encodes two polypeptides of 28K and 70K, which overlap in different reading frames; it is suggested that the third ORF in the 5' block is translated by frameshift readthrough near the end of the 70K protein, yielding a 118K polypeptide
[2]
. Segments of the predicted amino acid sequences of these ORFs resemble those of known viral RNA polymerases, ATP-binding proteins and viral genome-linked proteins. The nucleotide sequence of the genomic RNA of Beet western yellows virus (BWYV) has been determined
[4]
. The sequence contains six long ORFs. A cluster of three of these ORFs, including the coat protein cistron, display extensive amino acid sequence similarity to corresponding ORFs of a second luteovirus: Barley yellow dwarf virus
[4]
.

References
Imported from IPR018019

1.Sequencing, genomic localization and initial characterization of the VPg of pea enation mosaic enamovirus. Wobus CE, Skaf JS, Schultz MH, de Zoeten GA. J. Gen. Virol. 79 ( Pt 8), 2023-5, (1998). PMID: 9714253

2.Nucleotide sequence of potato leafroll luteovirus RNA. Mayo MA, Robinson DJ, Jolly CA, Hyman L. J. Gen. Virol. 70 ( Pt 5), 1037-51, (1989). PMID: 2732710

3.Nucleotide sequence and organization of potato leafroll virus genomic RNA. van der Wilk F, Huisman MJ, Cornelissen BJ, Huttinga H, Goldbach R. FEBS Lett. 245, 51-6, (1989). View articlePMID: 2466700

4.Nucleotide sequence of beet western yellows virus RNA. Veidt I, Lot H, Leiser M, Scheidecker D, Guilley H, Richards K, Jonard G. Nucleic Acids Res. 16, 9917-32, (1988). View articlePMID: 3194229

Supplementary References

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