PR00990

RIBOKINASE

PRINTS entry
Member databasePRINTS
PRINTS typefamily
Short nameRIBOKINASE

Description
Imported from IPR002139

Ribokinases participate in the first step of ribose metabolism, and are members of the superfamily of carbohydrate kinases. Ribokinases phosphorylate ribose to ribose-5-phosphate in the presence of ATP and magnesium
[5]
:

ATP + D-Ribose = ADP + D-Ribose-5-Phosphate

The phosphorylated sugar may then enter the pentose phosphate pathway
[1]
. There are indications that the phosphorylated sugar may also be used in the synthesis of amino acids (histidine and tryptophan). Further, links to mammalian adenosine kinase have been identified, through sequence similarity, suggesting possible homology
[1, 3]
.

This family also includes fructokinases
[4]
. Fructokinase may be involved in a sugar-sensing pathway in plants
[2, 8]
.

Other proteins included in this entry are: cytidine kinase from Thermococcus kodakarensis
[7]
, Sulfofructose kinase from Escherichia coli
[9]
, Pseudouridine kinase from Arabidopsis thaliana
[10]
, deoxyribokinase
[11]
and MJ0406 (
Q57849
) from Methanocaldococcus jannaschii. MJ0406 was previously annotated as a 6-phosphofructokinases (PFK), but has since been characterised as a functional nucleoside kinase
[6]
.

References
Imported from IPR002139

1.Cloning of human adenosine kinase cDNA: sequence similarity to microbial ribokinases and fructokinases. Spychala J, Datta NS, Takabayashi K, Datta M, Fox IH, Gribbin T, Mitchell BS. Proc. Natl. Acad. Sci. U.S.A. 93, 1232-7, (1996). View articlePMID: 8577746

2.Plant fructokinases: a sweet family get-together. Pego JV, Smeekens SC. Trends Plant Sci. 5, 531-6, (2000). View articlePMID: 11120475

3.Cloning and characterization of cDNA for adenosine kinase from mammalian (Chinese hamster, mouse, human and rat) species. High frequency mutants of Chinese hamster ovary cells involve structural alterations in the gene. Singh B, Hao W, Wu Z, Eigl B, Gupta RS. Eur. J. Biochem. 241, 564-71, (1996). View articlePMID: 8917457

4.Convergent evolution of similar enzymatic function on different protein folds: the hexokinase, ribokinase, and galactokinase families of sugar kinases. Bork P, Sander C, Valencia A. Protein Sci. 2, 31-40, (1993). View articlePMID: 8382990

5.Purification, characterization, and crystallization of Escherichia coli ribokinase. Sigrell JA, Cameron AD, Jones TA, Mowbray SL. Protein Sci. 6, 2474-6, (1997). View articlePMID: 9385653

6.The phosphofructokinase-B (MJ0406) from Methanocaldococcus jannaschii represents a nucleoside kinase with a broad substrate specificity. Hansen T, Arnfors L, Ladenstein R, Schonheit P. Extremophiles 11, 105-14, (2007). View articlePMID: 17021658

7.A pentose bisphosphate pathway for nucleoside degradation in Archaea. Aono R, Sato T, Imanaka T, Atomi H. Nat Chem Biol 11, 355-60, (2015). PMID: 25822915

8.Isolation and characterization of two fructokinase cDNA clones from rice. Jiang H, Dian W, Liu F, Wu P. Phytochemistry 62, 47-52, (2003). View articlePMID: 12475618

9.Sulphoglycolysis in Escherichia coli K-12 closes a gap in the biogeochemical sulphur cycle. Denger K, Weiss M, Felux AK, Schneider A, Mayer C, Spiteller D, Huhn T, Cook AM, Schleheck D. Nature 507, 114-7, (2014). View articlePMID: 24463506

10.A Kinase and a Glycosylase Catabolize Pseudouridine in the Peroxisome to Prevent Toxic Pseudouridine Monophosphate Accumulation. Chen M, Witte CP. Plant Cell 32, 722-739, (2020). PMID: 31907295

11.Genetic and biochemical characterization of Salmonella enterica serovar typhi deoxyribokinase. Tourneux L, Bucurenci N, Saveanu C, Kaminski PA, Bouzon M, Pistotnik E, Namane A, Marliere P, Barzu O, Li De La Sierra I, Neuhard J, Gilles AM. J Bacteriol 182, 869-73, (2000). View articlePMID: 10648508

Supplementary References

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