PR01022

OUTRMMBRANEA

PRINTS entry
Member databasePRINTS
PRINTS typefamily
Short nameOUTRMMBRANEA

Description
Imported from IPR002368

The OmpA outer membrane proteins in this group all contain the OmpA-like transmembrane domain at the N-terminal and the conserved bacterial outer membrane protein domain at the C-terminal. The outer membrane protein A of Escherichia coli (OmpA), is one of the most studied proteins in this group
[1]
. It has a multifunctional role. OmpA is required for the action of colicins K and L and for the stabilisation of mating aggregates in conjugation. OmpA may be involved in the maintenance of the position of the peptidoglycan cell wall in the periplasm by non-covalent interaction with TolR
[3]
. These proteins are implicated as a secondary receptor for a number of T-even like phages, for example, during phage Sf6 infection, it requires both lipopolysaccharide and OmpA
[4]
. In addition, OmpA can act as a porin with low permeability that allows slow penetration of small solutes
[2]
.

References
Imported from IPR002368

1.Expression and secretion of proteins in E. coli. Pines O, Inouye M. Mol. Biotechnol. 12, 25-34, (1999). View articlePMID: 10554771

2.The role of the mature part of secretory proteins in translocation across the plasma membrane and in regulation of their synthesis in Escherichia coli. MacIntyre S, Henning U. Biochimie 72, 157-67, (1990). View articlePMID: 1974149

3.Binding from Both Sides: TolR and Full-Length OmpA Bind and Maintain the Local Structure of the E. coli Cell Wall. Boags AT, Samsudin F, Khalid S. Structure 27, 713-724.e2, (2019). PMID: 30713026

4.OmpA and OmpC are critical host factors for bacteriophage Sf6 entry in Shigella. Parent KN, Erb ML, Cardone G, Nguyen K, Gilcrease EB, Porcek NB, Pogliano J, Baker TS, Casjens SR. Mol. Microbiol. 92, 47-60, (2014). PMID: 24673644

Supplementary References

1. Primary structure of major outer membrane protein II (ompA protein) of Escherichia coli K-12. Chen R, Schmidmayr W, Kramer C, Chen-Schmeisser U, Henning U. Proc. Natl. Acad. Sci. U.S.A. 77, 4592-6, (1980). View articlePMID: 7001461

2. Identification and characterization of the Treponema pallidum tpn50 gene, an ompA homolog. Hardham JM, Stamm LV. Infect. Immun. 62, 1015-25, (1994). View articlePMID: 8112835

3. Cloning and molecular characterization of the ompA gene from Salmonella typhimurium. Freudl R, Cole ST. Eur. J. Biochem. 134, 497-502, (1983). View articlePMID: 6349993

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