PR01764

MAPKPHPHTASE

PRINTS entry
Member databasePRINTS
PRINTS typefamily
Short nameMAPKPHPHTASE

Description
Imported from IPR008343

MAP Kinase Phosphatases (MKPs) are members of the dual specificity phosphatase family
[3, 2]
. MKPs constitute a class of phosphatases that reverse the activation of MAP (mitogen activated protein) kinases by dephosphorylating critical tyrosine and threonine residues
[4]
. This regulation is mediated via interaction of a Kinase Interaction Motif (KIM) with the common docking domain of the kinase -this motif is shared with a number of other protein families that interact with MAP kinases: these include kinases (MEKs), phosphatases (PTP-SL) and transcription factors (Elk1). MKPs also share an active site motif with the protein tyrosine phosphatases (PTPs). Different MKPs exhibit specificity towards different members of the MAP kinase family
[1]
.

The structure of the MPK catalytic domain is similar to that of the PTPs -the fold exhibits a complex mixed α/β-architecture. The catalytic mechanism involves a general acid (Asp92 in 1VHR) and a catalytic cysteine (130 in 1VHR), which acts as a nucleophile.

References
Imported from IPR008343

1.The dual specificity phosphatases M3/6 and MKP-3 are highly selective for inactivation of distinct mitogen-activated protein kinases. Muda M, Theodosiou A, Rodrigues N, Boschert U, Camps M, Gillieron C, Davies K, Ashworth A, Arkinstall S. J. Biol. Chem. 271, 27205-8, (1996). View articlePMID: 8910287

2.Protein tyrosine phosphatases in the human genome. Alonso A, Sasin J, Bottini N, Friedberg I, Friedberg I, Osterman A, Godzik A, Hunter T, Dixon J, Mustelin T. Cell 117, 699-711, (2004). View articlePMID: 15186772

3.Protein tyrosine phosphatases: from genes, to function, to disease. Tonks NK. Nat. Rev. Mol. Cell Biol. 7, 833-46, (2006). View articlePMID: 17057753

4.MKP-1 (3CH134), an immediate early gene product, is a dual specificity phosphatase that dephosphorylates MAP kinase in vivo. Sun H, Charles CH, Lau LF, Tonks NK. Cell 75, 487-93, (1993). View articlePMID: 8221888

Supplementary References

1. Crystal structure of the dual specificity protein phosphatase VHR. Yuvaniyama J, Denu JM, Dixon JE, Saper MA. Science 272, 1328-31, (1996). View articlePMID: 8650541

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