Member database | PRINTS |
PRINTS type | family |
Short name | SYNEMBRYN |
Description Imported from IPR008376
Synembryns are proteins that positively regulate synaptic transmission. They are actively required to maintain proper activity of the Go to Gq G-protein signalling network, which regulates neurotransmitter secretion in Caenorhabditis elegans by controlling the production and consumption of diacylglycerol
[1]. In addition to its role in the adult nervous system, synembryn is required to regulate a subset of centrosome movements in the early C. elegans embryo
[2].
The protein appears to be concentrated in the cytoplasm of neurons. However, unlike other protein components of the Go-Gq signalling network, synembryn appears to be more concentrated in the cell soma than in axonal processes throughout the nervous system
[1]. C. elegans synembryn reduction of function mutants exhibit partial embryonic lethality
[2].
References Imported from IPR008376
1.RIC-8 (Synembryn): a novel conserved protein that is required for G(q)alpha signaling in the C. elegans nervous system. Miller KG, Emerson MD, McManus JR, Rand JB. Neuron 27, 289-99, (2000). View articlePMID: 10985349
2.A role for RIC-8 (Synembryn) and GOA-1 (G(o)alpha) in regulating a subset of centrosome movements during early embryogenesis in Caenorhabditis elegans. Miller KG, Rand JB. Genetics 156, 1649-60, (2000). View articlePMID: 11102364
Supplementary References
1. Mammalian Ric-8A (synembryn) is a heterotrimeric Galpha protein guanine nucleotide exchange factor. Tall GG, Krumins AM, Gilman AG. J. Biol. Chem. 278, 8356-62, (2003). View articlePMID: 12509430