PR01802

SYNEMBRYN

PRINTS entry
Member databasePRINTS
PRINTS typefamily
Short nameSYNEMBRYN

Description
Imported from IPR008376

Synembryns are proteins that positively regulate synaptic transmission. They are actively required to maintain proper activity of the Go to Gq G-protein signalling network, which regulates neurotransmitter secretion in Caenorhabditis elegans by controlling the production and consumption of diacylglycerol
[1]
. In addition to its role in the adult nervous system, synembryn is required to regulate a subset of centrosome movements in the early C. elegans embryo
[2]
.

The protein appears to be concentrated in the cytoplasm of neurons. However, unlike other protein components of the Go-Gq signalling network, synembryn appears to be more concentrated in the cell soma than in axonal processes throughout the nervous system
[1]
. C. elegans synembryn reduction of function mutants exhibit partial embryonic lethality
[2]
.

References
Imported from IPR008376

1.RIC-8 (Synembryn): a novel conserved protein that is required for G(q)alpha signaling in the C. elegans nervous system. Miller KG, Emerson MD, McManus JR, Rand JB. Neuron 27, 289-99, (2000). View articlePMID: 10985349

2.A role for RIC-8 (Synembryn) and GOA-1 (G(o)alpha) in regulating a subset of centrosome movements during early embryogenesis in Caenorhabditis elegans. Miller KG, Rand JB. Genetics 156, 1649-60, (2000). View articlePMID: 11102364

Supplementary References

1. Mammalian Ric-8A (synembryn) is a heterotrimeric Galpha protein guanine nucleotide exchange factor. Tall GG, Krumins AM, Gilman AG. J. Biol. Chem. 278, 8356-62, (2003). View articlePMID: 12509430

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