PS50297

Ankyrin repeat region circular profile

PROSITE profiles entry
Member databasePROSITE profiles
PROSITE profiles typedomain
Short nameANK_REP_REGION

Description

Ankyrin repeats (ANK) are tandemly repeated modules of about 33 amino acids. They occur in a large number of functionally diverse proteins mainly from eukaryotes. The few known examples from prokaryotes and viruses may be the result of horizontal gene transfers
[4]
. Many ankyrin repeat regions are known to function as protein-protein interaction domains. The conserved fold of the ankyrin repeat unit is known from several crystal and solution structures, e.g. from: - p53-binding protein 53BP2
[5]
, - Cyclin-dependent kinase inhibitor p19Ink4d
[1]
, - Transcriptional regulator GABP-beta
[2]
, - NF-kappaB inhibitory protein IkB-alpha
[3]
. It has been described as an L-shaped structure consisting of a beta-hairpin and two alpha-helices
[5]
. Two profiles were developed for this module, the first one picks up ANK repeats while the second profile is 'circular' and will thus detect a region containing adjacent ANK repeats.

References

1.Structure of the cyclin-dependent kinase inhibitor p19Ink4d. Luh FY, Archer SJ, Domaille PJ, Smith BO, Owen D, Brotherton DH, Raine AR, Xu X, Brizuela L, Brenner SL, Laue ED. Nature 389, 999-1003, (1997). View articlePMID: 9353127

2.The structure of GABPalpha/beta: an ETS domain- ankyrin repeat heterodimer bound to DNA. Batchelor AH, Piper DE, de la Brousse FC, McKnight SL, Wolberger C. Science 279, 1037-41, (1998). View articlePMID: 9461436

3.Structure of an IkappaBalpha/NF-kappaB complex. Jacobs MD, Harrison SC. Cell 95, 749-58, (1998). View articlePMID: 9865693

4.Hundreds of ankyrin-like repeats in functionally diverse proteins: mobile modules that cross phyla horizontally? Bork P. Proteins 17, 363-74, (1993). View articlePMID: 8108379

5.Structure of the p53 tumor suppressor bound to the ankyrin and SH3 domains of 53BP2. Gorina S, Pavletich NP. Science 274, 1001-5, (1996). View articlePMID: 8875926

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