PS50887

GGDEF domain profile

PROSITE profiles entry
Member databasePROSITE profiles
PROSITE profiles typedomain
Short nameGGDEF

Description

The GGDEF domain, which has been named after the conserved central sequence pattern GG[DE][DE]F is widespread in prokaryotes. It is typically present in multidomain proteins containing regulatory domains of signaling pathways or protein-protein or protein-ligand interaction modules, such as the response regulatory domain, the PAS/PAC domain, the HAMP domain, the GAF domain, the FHA domain or the TPR repeat. However a few single-domain proteins are also known. The GGDEF domain is involved in signal transduction and is likely to catalyze synthesis or hydrolysis of cyclic diguanylate (c-diGMP, bis(3',5')-cyclic diguanylic acid), an effector molecule that consists of two cGMP moieties bound head-to-tail
[1]
[2]
[3]
. Some proteins known to contain a GGDEF domain are listed below: - Acetobacter xylinus diguanylate cyclases (DGCs) and c-di-GMP phosphodiesterases A (PDEAs). - Bacillus subtilis hypothetical protein yhcK. - Caulobacter crescentus pleD protein, a response regulator that controls cell differentiation in the swarmer-to-stalked cell transition. - Rhizobium celR2, a putative response regulator protein. - Salmonella protein adrA. The profile we developed covers the entire GGDEF domain.

References

1.Novel domains of the prokaryotic two-component signal transduction systems. Galperin MY, Nikolskaya AN, Koonin EV. FEMS Microbiol. Lett. 203, 11-21, (2001). View articlePMID: 11557134

2.Genetic data indicate that proteins containing the GGDEF domain possess diguanylate cyclase activity. Ausmees N, Mayer R, Weinhouse H, Volman G, Amikam D, Benziman M, Lindberg M. FEMS Microbiol. Lett. 204, 163-7, (2001). View articlePMID: 11682196

3.GGDEF domain is homologous to adenylyl cyclase. Pei J, Grishin NV. Proteins 42, 210-6, (2001). View articlePMID: 11119645

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