Member database | PROSITE profiles |
PROSITE profiles type | domain |
Short name | GGDEF |
Description
The GGDEF domain, which has been named after the conserved central sequence
pattern GG[DE][DE]F is widespread in prokaryotes. It is typically present in
multidomain proteins containing regulatory domains of signaling pathways or
protein-protein or protein-ligand interaction modules, such as the response
regulatory domain, the
PAS/PAC domain, the HAMP domain, the
GAF domain, the FHA domain or the TPR repeat. However a
few single-domain proteins are also known. The GGDEF domain is involved in
signal transduction and is likely to catalyze synthesis or hydrolysis of
cyclic diguanylate (c-diGMP, bis(3',5')-cyclic diguanylic acid), an effector
molecule that consists of two cGMP moieties bound head-to-tail
[1][2][3].
Some proteins known to contain a GGDEF domain are listed below:
- Acetobacter xylinus diguanylate cyclases (DGCs) and c-di-GMP
phosphodiesterases A (PDEAs).
- Bacillus subtilis hypothetical protein yhcK.
- Caulobacter crescentus pleD protein, a response regulator that controls
cell differentiation in the swarmer-to-stalked cell transition.
- Rhizobium celR2, a putative response regulator protein.
- Salmonella protein adrA.
The profile we developed covers the entire GGDEF domain.
References
1.Novel domains of the prokaryotic two-component signal transduction systems. Galperin MY, Nikolskaya AN, Koonin EV. FEMS Microbiol. Lett. 203, 11-21, (2001). View articlePMID: 11557134
2.Genetic data indicate that proteins containing the GGDEF domain possess diguanylate cyclase activity. Ausmees N, Mayer R, Weinhouse H, Volman G, Amikam D, Benziman M, Lindberg M. FEMS Microbiol. Lett. 204, 163-7, (2001). View articlePMID: 11682196
3.GGDEF domain is homologous to adenylyl cyclase. Pei J, Grishin NV. Proteins 42, 210-6, (2001). View articlePMID: 11119645
Integrated to
External Links
Representative structure
6eib: Structure of the active GGEEF domain of a diguanylate cyclase from Vibrio cholerae.