PS50901

FtsK domain profile

PROSITE profiles entry
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PROSITE profiles typedomain
Short nameFTSK

Description

The FtsK domain is a hydrophilic domain of about 200 residues, which is found in: - Bacterial cell division protein ftsK (known as sporulation protein SpoIIIE in Bacillus subtilis). - A set of conjugative plasmid- and conjugative transposon-encoded proteins, generally called Tra proteins. These proteins come from an extremly wide range of species, including Gram-positive and Gram-negative bacilli and cocci, Streptomyces species, Agrobacterium spp., and archaebacteria. In cases in which a function is known, the protein is required for intercellular DNA transfer. The FtsK domain contains a highly conserved putative ATP-binding P-loop motif and is assumed to be cytoplasmic. It can be found in one to three copies and is thought to be involved in DNA translocation by coupling ATP hydrolysis to movement relative to the long axis of DNA
[2]
[1]
[3]
. The profile we developed covers the entire FtsK domain.

References

1.DNA transport in bacteria. Errington J, Bath J, Wu LJ. Nat. Rev. Mol. Cell Biol. 2, 538-45, (2001). View articlePMID: 11433368

2.A new Escherichia coli cell division gene, ftsK. Begg KJ, Dewar SJ, Donachie WD. J. Bacteriol. 177, 6211-22, (1995). View articlePMID: 7592387

3.The ESAT-6/WXG100 superfamily -- and a new Gram-positive secretion system? Pallen MJ. Trends Microbiol. 10, 209-12, (2002). View articlePMID: 11973144

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