Member database | PROSITE profiles |
PROSITE profiles type | domain |
Short name | FTSK |
Description
The FtsK domain is a hydrophilic domain of about 200 residues, which is found
in:
- Bacterial cell division protein ftsK (known as sporulation protein SpoIIIE
in Bacillus subtilis).
- A set of conjugative plasmid- and conjugative transposon-encoded proteins,
generally called Tra proteins. These proteins come from an extremly wide
range of species, including Gram-positive and Gram-negative bacilli and
cocci, Streptomyces species, Agrobacterium spp., and archaebacteria. In
cases in which a function is known, the protein is required for
intercellular DNA transfer.
The FtsK domain contains a highly conserved putative ATP-binding P-loop motif and is assumed to be cytoplasmic. It can be found in one to
three copies and is thought to be involved in DNA translocation by coupling
ATP hydrolysis to movement relative to the long axis of DNA
[2][1][3].
The profile we developed covers the entire FtsK domain.
References
1.DNA transport in bacteria. Errington J, Bath J, Wu LJ. Nat. Rev. Mol. Cell Biol. 2, 538-45, (2001). View articlePMID: 11433368
2.A new Escherichia coli cell division gene, ftsK. Begg KJ, Dewar SJ, Donachie WD. J. Bacteriol. 177, 6211-22, (1995). View articlePMID: 7592387
3.The ESAT-6/WXG100 superfamily -- and a new Gram-positive secretion system? Pallen MJ. Trends Microbiol. 10, 209-12, (2002). View articlePMID: 11973144