Member database | PROSITE profiles |
PROSITE profiles type | domain |
Short name | TROVE |
Description
The TROVE (Telomerase, Ro and Vault) domain is a module of ~300-500 residues
that is found in TEP1 and Ro60 the protein components of three
ribonucleoprotein particles. The TROVE domain is also found in bacterial
ribonucleoproteins suggesting an ancient origin of these ribonucleoproteins.
The TROVE domain can be found associated with other domains, such as the VWFA
domain, the TEP1 N-terminal domain, the NACHT-NTPase domain, and WD-40 repeats. The TROVE domain may
be involved in binding the RNA components of the three RNPs, which are
telomerase RNA, Y RNA and vault RNA
[1].
The TROVE domain contains a few absolutely conserved residues. As none of
these conserved residues are the polar type of amino acids found in active
sites, it seems unlikely that this region has an enzymatic function
[1].
The profile we developed covers the entire TROVE domain.
References
1.The TROVE module: a common element in Telomerase, Ro and Vault ribonucleoproteins. Bateman A, Kickhoefer V. BMC Bioinformatics 4, 49, (2003). View articlePMID: 14563212