PS51229

DCUN1 domain profile

PROSITE profiles entry
Member databasePROSITE profiles
PROSITE profiles typedomain
Short nameDCUN1

Description

The DCUN1 domain is an ~190-residue module found in the eukaryotic defective in cullin neddylation (DCN) protein family, which includes: - Yeast DCN1. - Vertebrate DCN1-like protein 1. - Vertebrate DCN1-like protein 2. - Vertebrate DCN1-like protein 4. Proteins of the DCN family may contribute to neddylation of cullin components of SCF-type E3 ubiquitin ligase complexes, which are multi-protein complexes required for polyubiquitination and subsequent degradation of target proteins by the 26S proteasome
[1]
. Although the DCUN1 domain function is unknown, it has been suggested that it has features of a basic helix-loop-helix leucine zipper (bHLH-ZIP) domain
[2]
. The DCUN1 domain can be found in association with an UBA-like domain
[1]
. The profile we developed covers the entire DCUN1 domain.

References

1.The conserved protein DCN-1/Dcn1p is required for cullin neddylation in C. elegans and S. cerevisiae. Kurz T, Ozlu N, Rudolf F, O'Rourke SM, Luke B, Hofmann K, Hyman AA, Bowerman B, Peter M. Nature 435, 1257-61, (2005). View articlePMID: 15988528

2.A new family of genes and pseudogenes potentially expressing testis- and brain-specific leucine zipper proteins in man and mouse. Pourcel C, Jaubert J, Hadchouel M, Wu X, Schweizer J. Gene 249, 105-13, (2000). View articlePMID: 10831844

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