Member database | PROSITE profiles |
PROSITE profiles type | domain |
Short name | DOC |
Description
The anaphase-promoting complex (APC) is a multi-subunit E3 protein ubiquitin
ligase that is reponsible for the metaphase to anaphase transition and the
exit from mitosis. The subunit APC10 is a one-domain protein homologous to a
sequence element, termed the DOC domain, found in several hypothetical
proteins that may also mediate ubiquitination reactions, because they contain
combinations of either RING finger, cullin
or HECT domains
[1][2][3].
The DOC domain consists of a beta-sandwich, in which a five-stranded
antiparallel beta-sheet is packed on top of a three stranded antiparallel
beta-sheet, exhibiting a 'jellyroll' fold
[2][3].
Some proteins known to contain a DOC domain are listed below:
- Eucaryotic Doc1/Apc10.
- Mammalian protein associated with the transcription factor Myc (PAM).
- Mouse runty-jerky-sterile (RJS) protein.
- Human HERC2, the ortholog of RJS.
The profile we developed covers the entire DOC domain.
References
1.Characterization of the DOC1/APC10 subunit of the yeast and the human anaphase-promoting complex. Grossberger R, Gieffers C, Zachariae W, Podtelejnikov AV, Schleiffer A, Nasmyth K, Mann M, Peters JM. J. Biol. Chem. 274, 14500-7, (1999). View articlePMID: 10318877
2.Crystal structure of the APC10/DOC1 subunit of the human anaphase-promoting complex. Wendt KS, Vodermaier HC, Jacob U, Gieffers C, Gmachl M, Peters JM, Huber R, Sondermann P. Nat. Struct. Biol. 8, 784-8, (2001). View articlePMID: 11524682
3.Implications for the ubiquitination reaction of the anaphase-promoting complex from the crystal structure of the Doc1/Apc10 subunit. Au SW, Leng X, Harper JW, Barford D. J. Mol. Biol. 316, 955-68, (2002). View articlePMID: 11884135