PS51284

DOC domain profile

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Short nameDOC

Description

The anaphase-promoting complex (APC) is a multi-subunit E3 protein ubiquitin ligase that is reponsible for the metaphase to anaphase transition and the exit from mitosis. The subunit APC10 is a one-domain protein homologous to a sequence element, termed the DOC domain, found in several hypothetical proteins that may also mediate ubiquitination reactions, because they contain combinations of either RING finger, cullin or HECT domains
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[2]
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. The DOC domain consists of a beta-sandwich, in which a five-stranded antiparallel beta-sheet is packed on top of a three stranded antiparallel beta-sheet, exhibiting a 'jellyroll' fold
[2]
[3]
. Some proteins known to contain a DOC domain are listed below: - Eucaryotic Doc1/Apc10. - Mammalian protein associated with the transcription factor Myc (PAM). - Mouse runty-jerky-sterile (RJS) protein. - Human HERC2, the ortholog of RJS. The profile we developed covers the entire DOC domain.

References

1.Characterization of the DOC1/APC10 subunit of the yeast and the human anaphase-promoting complex. Grossberger R, Gieffers C, Zachariae W, Podtelejnikov AV, Schleiffer A, Nasmyth K, Mann M, Peters JM. J. Biol. Chem. 274, 14500-7, (1999). View articlePMID: 10318877

2.Crystal structure of the APC10/DOC1 subunit of the human anaphase-promoting complex. Wendt KS, Vodermaier HC, Jacob U, Gieffers C, Gmachl M, Peters JM, Huber R, Sondermann P. Nat. Struct. Biol. 8, 784-8, (2001). View articlePMID: 11524682

3.Implications for the ubiquitination reaction of the anaphase-promoting complex from the crystal structure of the Doc1/Apc10 subunit. Au SW, Leng X, Harper JW, Barford D. J. Mol. Biol. 316, 955-68, (2002). View articlePMID: 11884135

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