PS51329

C-CAP/cofactor C-like domain profile

PROSITE profiles entry
Member databasePROSITE profiles
PROSITE profiles typedomain
Short nameC_CAP_COFACTOR_C

Description

The C-CAP/cofactor C-like domain is present in several cytoskeleton-related proteins, which also contain a number of additional domains
[4]
[3]
[1]
[2]
: - Eukaryotic cyclase-associated protein (CAP or SRV2), a modular actin monomer binding that directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localization and the establishment of cell polarity. - Vertebrate retinitis pigmentosa 2 (XRP2). In human, the protein responsible for X-linked forms of retinitis pigmentosa, a disease characterized by severe retinal degeneration. - Eukaryotic tubulin-specific chaperone cofactor C (TBCC), a GTPase- activating component of the tubulin-folding supercomplex, which directs the assembly of the alpha- and beta-tubulin heterodimer. The cyclase-associated protein C-CAP/cofactor C-like domain binds G-actin and is responsible for oligomerization of the entire CAP molecule
[4]
, whereas the XRP2 C-CAP/cofactor C-like domain is required for binding of ADP ribosylation factor-like protein 3 (Arl3)
[3]
. The central core of the C-CAP/cofactor C-like domain is composed of six coils of right-handed parallel beta-helix, termed coils 1-6, which form an elliptical barrel with a tightly packed interior. Each beta-helical coil is composed of three relatively short beta-strands, designated a-c, separated by sharp turns. Flanking the central beta-helical core is an N-terminal beta- strand, beta0, that packs antiparallel to the core, and strand beta7 packs antiparallel to the core near the C-terminal end of the parallel beta-helix
[4]
[3]
. The profile we developed covers the C-CAP/cofactor C-like domain.

References

1.An essential quality control mechanism at the eukaryotic basal body prior to intraflagellar transport. Stephan A, Vaughan S, Shaw MK, Gull K, McKean PG. Traffic 8, 1323-30, (2007). View articlePMID: 17645436

2.Domain analysis of the tubulin cofactor system: a model for tubulin folding and dimerization. Grynberg M, Jaroszewski L, Godzik A. BMC Bioinformatics 4, 46, (2003). View articlePMID: 14536023

3.Crystal structure of the human retinitis pigmentosa 2 protein and its interaction with Arl3. Kuhnel K, Veltel S, Schlichting I, Wittinghofer A. Structure 14, 367-78, (2006). View articlePMID: 16472755

4.Crystal structure of the actin binding domain of the cyclase-associated protein. Dodatko T, Fedorov AA, Grynberg M, Patskovsky Y, Rozwarski DA, Jaroszewski L, Aronoff-Spencer E, Kondraskina E, Irving T, Godzik A, Almo SC. Biochemistry 43, 10628-41, (2004). View articlePMID: 15311924

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