PS51839

His(Cys)3-ligated-type [4Fe-4S] domain profile

PROSITE profiles entry
Member databasePROSITE profiles
PROSITE profiles typedomain
Short name4FE4S_HC3

Description

The following proteins contain a His(Cys)3-ligated-type [4Fe-4S] domain that consists of just two alpha helices separated by a loop region that coordinates a [4Fe-4S] cluster through an unusual H-x(3)-C-x(2)-C-x(5)-C motif that includes one His and three Cys residues
[2]
[1]
[3]
[4]
[5]
[6]
: - Prokaryotic and mitochondrial NuoG/Nqo3 subunit (75 kDa) of NADH:ubiquinone oxidoreductase (complex I). - Clostridium pasteurianum of the iron-only hydrogenase (CpI) (EC:1.12.7.2). - Ralstonia eutropha NAD-dependent formate dehydrogenase alpha subunit (FdsA). - Moorella thermoacetica formate dehydrogenase alpha subunit (FdhA). - Desulfovibrio fructosivorans NADP-reducing hydrogenase subunit HndD. - Clostridium pasteurianum - Ralstonia eutropha NAD-reducing [Ni-Fe] hydrogenase (H2:NAD oxidoreductase) (HoxU). Its motif for the [4Fe-4S] cluster is G-x-H-x-C-x(2)-C-x(5)-C. The profile we developed covers the entire His(Cys)3-ligated-type [4Fe-4S] domain.

References

1.X-ray crystal structure of the Fe-only hydrogenase (CpI) from Clostridium pasteurianum to 1.8 angstrom resolution. Peters JW, Lanzilotta WN, Lemon BJ, Seefeldt LC. Science 282, 1853-8, (1998). View articlePMID: 9836629

2.Structural analysis of the fds operon encoding the NAD+-linked formate dehydrogenase of Ralstonia eutropha. Oh JI, Bowien B. J. Biol. Chem. 273, 26349-60, (1998). View articlePMID: 9756865

3.A novel FeS cluster in Fe-only hydrogenases. Nicolet Y, Lemon BJ, Fontecilla-Camps JC, Peters JW. Trends Biochem. Sci. 25, 138-43, (2000). View articlePMID: 10694885

4.Characterization of cluster N5 as a fast-relaxing [4Fe-4S] cluster in the Nqo3 subunit of the proton-translocating NADH-ubiquinone oxidoreductase from Paracoccus denitrificans. Yano T, Sklar J, Nakamaru-Ogiso E, Takahashi Y, Yagi T, Ohnishi T. J Biol Chem 278, 15514-22, (2003). PMID: 12600982

5.Structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus. Sazanov LA, Hinchliffe P. Science 311, 1430-6, (2006). View articlePMID: 16469879

6.Iron-sulfur cluster N5 is coordinated by an HXXXCXXCXXXXXC motif in the NuoG subunit of Escherichia coli NADH:quinone oxidoreductase (complex I). Nakamaru-Ogiso E, Matsuno-Yagi A, Yoshikawa S, Yagi T, Ohnishi T. J. Biol. Chem. 283, 25979-87, (2008). View articlePMID: 18603533

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