PS00214

Cytosolic fatty-acid binding proteins signature

PROSITE patterns entry
Member databasePROSITE patterns
PROSITE patterns typeconserved site
Short nameFABP

Description

A number of low molecular weight proteins which bind fatty acids and other organic anions are present in the cytosol
[6]
[3]
. Most of them are structurally related and have probably diverged from a common ancestor. This structure is a ten stranded antiparallel beta-barrel, albeit with a wide discontinuity between the fourth and fifth strands, with a repeated + 1 topology enclosing a internal ligand binding site
[3]
[5]
. Proteins known to belong to this family include: - Six, tissue-specific, types of fatty acid binding proteins (FABPs) found in liver, intestine, heart, epidermal, adipocyte, brain/retina. Heart FABP is also known as mammary-derived growth inhibitor (MDGI), a protein that reversibly inhibits proliferation of mammary carcinoma cells. Epidermal FABP is also known as psoriasis-associated FABP
[1]
. - Insect muscle fatty acid-binding proteins. - Testis lipid binding protein (TLBP). - Cellular retinol-binding proteins I and II (CRBP). - Cellular retinoic acid-binding protein (CRABP). - Gastrotropin, an ileal protein which stimulates gastric acid and pepsinogen secretion. It seems that gastrotropin binds to bile salts and bilirubins. - Fatty acid binding proteins MFB1 and MFB2 from the midgut of the insect Manduca sexta
[2]
. In addition to the above cytosolic proteins, this family also includes: - Myelin P2 protein, which may be a lipid transport protein in Schwann cells. P2 is associated with the lipid bilayer of myelin. - Schistosoma mansoni protein Sm14
[4]
which seems to be involved in the transport of fatty acids. - Ascaris suum p18 a secreted protein that may play a role in sequestering potentially toxic fatty acids and their peroxidation products or that may be involved in the maintenance of the impermeable lipid layer of the eggshell. - Hypothetical fatty acid-binding proteins F40F4.2, F40F4.3, F40F4.4 and ZK742.5 from Caenorhabditis elegans. We use as a signature pattern for these proteins a segment from the N-terminal extremity.

References

1.Purification and characterization of the human epidermal fatty acid-binding protein: localization during epidermal cell differentiation in vivo and in vitro. Siegenthaler G, Hotz R, Chatellard-Gruaz D, Didierjean L, Hellman U, Saurat JH. Biochem. J. 302 ( Pt 2), 363-71, (1994). View articlePMID: 8092987

2.Isolation, characterization, and cDNA sequence of two fatty acid-binding proteins from the midgut of Manduca sexta larvae. Smith AF, Tsuchida K, Hanneman E, Suzuki TC, Wells MA. J. Biol. Chem. 267, 380-4, (1992). View articlePMID: 1730603

3.Expression of human liver fatty acid-binding protein in Escherichia coli and comparative analysis of its binding characteristics with muscle fatty acid-binding protein. Maatman RG, van Moerkerk HT, Nooren IM, van Zoelen EJ, Veerkamp JH. Biochim. Biophys. Acta 1214, 1-10, (1994). View articlePMID: 8068722

4.A 14-kDa Schistosoma mansoni polypeptide is homologous to a gene family of fatty acid binding proteins. Moser D, Tendler M, Griffiths G, Klinkert MQ. J. Biol. Chem. 266, 8447-54, (1991). View articlePMID: 2022660

5.Structural relationship of streptavidin to the calycin protein superfamily. Flower DR. FEBS Lett. 333, 99-102, (1993). View articlePMID: 8224179

6.A survey on cytosolic non-enzymic proteins involved in the metabolism of lipophilic compounds: from organic anion binders to new protein families. Bernier I, Jolles P. Biochimie 69, 1127-52, (1987). View articlePMID: 3129018

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