PS00240

Receptor tyrosine kinase class III signature

PROSITE patterns entry
Member databasePROSITE patterns
PROSITE patterns typeconserved site
Short nameRECEPTOR_TYR_KIN_III

Description

A number of growth factors stimulate mitogenesis by interacting with a family of cell surface receptors which possess an intrinsic, ligand-sensitive, protein tyrosine kinase activity
[6]
. These receptor tyrosine kinases (RTK) all share the same topology: an extracellular ligand-binding domain, a single transmembrane region and a cytoplasmic kinase domain. However they can be classified into at least five groups. The class III RTK's are characterized by the presence of five to seven immunoglobulin-like domains
[3]
in their extracellular section. Their kinase domain differs from that of other RTK's by the insertion of a stretch of 70 to 100 hydrophilic residues in the middle of this domain. The receptors currently known to belong to class III are: - Platelet-derived growth factor receptor (PDGF-R). PDGF-R exists as a homo- or heterodimer of two related chains: alpha and beta
[4]
. - Macrophage colony stimulating factor receptor (CSF-1-R) (also known as the fms oncogene). - Stem cell factor (mast cell growth factor) receptor (also known as the kit oncogene). - Vascular endothelial growth factor (VEGF) receptors Flt-1 and Flk-1/KDR
[5]
. - Fl cytokine receptor Flk-2/Flt-3
[2]
. - The putative receptor Flt-4
[1]
. We developed a signature pattern for this class of RTK's which is based on a conserved region in the kinase domain.

References

1.The FLT4 gene encodes a transmembrane tyrosine kinase related to the vascular endothelial growth factor receptor. Galland F, Karamysheva A, Pebusque MJ, Borg JP, Rottapel R, Dubreuil P, Rosnet O, Birnbaum D. Oncogene 8, 1233-40, (1993). PMID: 8386825

2.Molecular cloning of a ligand for the flt3/flk-2 tyrosine kinase receptor: a proliferative factor for primitive hematopoietic cells. Lyman SD, James L, Vanden Bos T, de Vries P, Brasel K, Gliniak B, Hollingsworth LT, Picha KS, McKenna HJ, Splett RR. Cell 75, 1157-67, (1993). View articlePMID: 7505204

3.Diversity of the immunoglobulin gene superfamily. Hunkapiller T, Hood L. Adv. Immunol. 44, 1-63, (1989). PMID: 2646860

4.Isolation and characterization of the alpha platelet-derived growth factor receptor from rat olfactory epithelium. Lee KH, Bowen-Pope DF, Reed RR. Mol. Cell. Biol. 10, 2237-46, (1990). View articlePMID: 2157969

5.Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factor. Terman BI, Dougher-Vermazen M, Carrion ME, Dimitrov D, Armellino DC, Gospodarowicz D, Bohlen P. Biochem. Biophys. Res. Commun. 187, 1579-86, (1992). View articlePMID: 1417831

6.Growth factor receptor tyrosine kinases. Yarden Y, Ullrich A. Annu. Rev. Biochem. 57, 443-78, (1988). View articlePMID: 3052279

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