PS00461

6-phosphogluconate dehydrogenase signature

PROSITE patterns entry
Member databasePROSITE patterns
PROSITE patterns typeconserved site
Short name6PGD

Description

6-phosphogluconate dehydrogenase (EC 1.1.1.44) (6PGD) catalyzes the third step in the hexose monophosphate shunt, the decarboxylating reduction of 6-phosphogluconate in to ribulose 5-phosphate. Prokaryotic and eukaryotic 6PGD are proteins of about 470 amino acids whose sequence are highly conserved
[1]
. As a signature pattern we have selected a region which has been shown
[2]
, from studies of the sheep 6PGD tertiary structure, to be involved in the binding of 6-phosphogluconate.

References

1.Analysis of the gluconate (gnt) operon of Bacillus subtilis. Reizer A, Deutscher J, Saier MH Jr, Reizer J. Mol. Microbiol. 5, 1081-9, (1991). View articlePMID: 1659648

2.The three dimensional structure of sheep liver 6-phosphogluconate dehydrogenase at 2.6 A resolution. Adams MJ, Archibald IG, Bugg CE, Carne A, Gover S, Helliwell JR, Pickersgill RW, White SW. EMBO J. 2, 1009-14, (1983). View articlePMID: 6641716

This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our Privacy Notice and Terms of Use.