Member database | PROSITE patterns |
PROSITE patterns type | conserved site |
Short name | 6PGD |
Description
6-phosphogluconate dehydrogenase (EC 1.1.1.44) (6PGD) catalyzes the third step
in the hexose monophosphate shunt, the decarboxylating reduction of
6-phosphogluconate in to ribulose 5-phosphate.
Prokaryotic and eukaryotic 6PGD are proteins of about 470 amino acids whose
sequence are highly conserved
[1]. As a signature pattern we have selected a
region which has been shown
[2], from studies of the sheep 6PGD tertiary
structure, to be involved in the binding of 6-phosphogluconate.
References
1.Analysis of the gluconate (gnt) operon of Bacillus subtilis. Reizer A, Deutscher J, Saier MH Jr, Reizer J. Mol. Microbiol. 5, 1081-9, (1991). View articlePMID: 1659648
2.The three dimensional structure of sheep liver 6-phosphogluconate dehydrogenase at 2.6 A resolution. Adams MJ, Archibald IG, Bugg CE, Carne A, Gover S, Helliwell JR, Pickersgill RW, White SW. EMBO J. 2, 1009-14, (1983). View articlePMID: 6641716