PS00558

Eukaryotic mitochondrial porin signature

PROSITE patterns entry
Member databasePROSITE patterns
PROSITE patterns typeconserved site
Short nameEUKARYOTIC_PORIN

Description

The major protein of the outer mitochondrial membrane of eukaryotes is a porin that forms a voltage-dependent anion-selective channel (VDAC) that behaves as a general diffusion pore for small hydrophilic molecules
[1]
[2]
[3]
. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. This protein contains about 280 amino acids and its sequence is composed of between 12 to 16 beta-strands that span the mitochondrial outer membrane. Yeast contains two members of this family (genes POR1 and POR2); vertebrates have at least three members (genes VDAC1, VDAC2 and VDAC3)
[4]
. As a signature pattern we selected a conserved region located at the C- terminal part of these proteins.

References

1.Permeation of hydrophilic solutes through mitochondrial outer membranes: review on mitochondrial porins. Benz R. Biochim. Biophys. Acta 1197, 167-96, (1994). View articlePMID: 8031826

2.The biogenesis and function of eukaryotic porins. Dihanich M. Experientia 46, 146-53, (1990). View articlePMID: 1689252

3.Molecular genetics of the VDAC ion channel: structural model and sequence analysis. Forte M, Guy HR, Mannella CA. J. Bioenerg. Biomembr. 19, 341-50, (1987). View articlePMID: 2442148

4.A novel mouse mitochondrial voltage-dependent anion channel gene localizes to chromosome 8. Sampson MJ, Lovell RS, Davison DB, Craigen WJ. Genomics 36, 192-6, (1996). View articlePMID: 8812436

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