PS00584

pfkB family of carbohydrate kinases signature 2

PROSITE patterns entry
Member databasePROSITE patterns
PROSITE patterns typeconserved site
Short namePFKB_KINASES_2

Description

It has been shown
[2]
[1]
[3]
that the following carbohydrate and purine kinases are evolutionary related and can be grouped into a single family, which is known
[2]
as the 'pfkB family': - Fructokinase (EC 2.7.1.4) (gene scrK). - 6-phosphofructokinase isozyme 2 (EC 2.7.1.11) (phosphofructokinase-2) (gene pfkB). pfkB is a minor phosphofructokinase isozyme in Escherichia coli and is not evolutionary related to the major isozyme (gene pfkA). Plants 6-phosphofructokinase also belong to this family. - Ribokinase (EC 2.7.1.15) (gene rbsK). - Adenosine kinase (EC 2.7.1.20) (gene ADK). - 2-dehydro-3-deoxygluconokinase (EC 2.7.1.45) (gene: kdgK). - 1-phosphofructokinase (EC 2.7.1.56) (fructose 1-phosphate kinase) (gene fruK). - Inosine-guanosine kinase (EC 2.7.1.73) (gene gsk). - Tagatose-6-phosphate kinase (EC 2.7.1.144) (phosphotagatokinase) (gene lacC). - Escherichia coli hypothetical protein yeiC. - Escherichia coli hypothetical protein yeiI. - Escherichia coli hypothetical protein yhfQ. - Escherichia coli hypothetical protein yihV. - Bacillus subtilis hypothetical protein yxdC. - Yeast hypothetical protein YJR105w. All the above kinases are proteins of from 280 to 430 amino acid residues that share a few region of sequence similarity. We have selected two of these regions as signature patterns. The first pattern is based on a region rich in glycine which is located in the N-terminal section of these enzymes; while the second pattern is based on a conserved region in the C-terminal section.

References

1.Sequence similarities between the gene specifying 1-phosphofructokinase (fruK), genes specifying other kinases in Escherichia coli K12, and lacC of Staphylococcus aureus. Orchard LM, Kornberg HL. Proc. Biol. Sci. 242, 87-90, (1990). View articlePMID: 1981619

2.Nucleotide sequence of the Rhodobacter capsulatus fruK gene, which encodes fructose-1-phosphate kinase: evidence for a kinase superfamily including both phosphofructokinases of Escherichia coli. Wu LF, Reizer A, Reizer J, Cai B, Tomich JM, Saier MH Jr. J. Bacteriol. 173, 3117-27, (1991). View articlePMID: 1850730

3.Nucleotide sequence and analysis of the Vibrio alginolyticus sucrose uptake-encoding region. Blatch GL, Scholle RR, Woods DR. Gene 95, 17-23, (1990). View articlePMID: 2174811

This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our Privacy Notice and Terms of Use.