PS00855

Signal peptidases II signature

PROSITE patterns entry
Member databasePROSITE patterns
PROSITE patterns typeconserved site
Short nameSPASE_II

Description

Signal peptidases (SPases)
[1]
(also known as leader peptidases) remove the signal peptides from secretory proteins. In prokaryotes three types of SPases are known: type I (gene lepB) which is responsible for the processing of the majority of exported pre-proteins; type II (gene lsp) which only process lipoproteins, and a third type involved in the processing of pili subunits. SPase II (EC 3.4.23.36), also known as lipoprotein signal peptidase, recognizes a conserved sequence and cuts in front of a cysteine residue to which a glyceride-fatty acid lipid is attached. SPase II is an integral membrane protein that is anchored in the cytoplasmic membrane. There are a number of conserved regions in the sequence of Spase II from various bacteria
[2]
, we have selected one of these regions as a signature pattern.

References

1.Signal peptidases in prokaryotes and eukaryotes--a new protease family. Dalbey RE, Von Heijne G. Trends Biochem. Sci. 17, 474-8, (1992). View articlePMID: 1455520

2.Nucleotide sequence of the Staphylococcus aureus signal peptidase II (lsp) gene. Zhao XJ, Wu HC. FEBS Lett. 299, 80-4, (1992). View articlePMID: 1544479

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