PS01003

Translationally controlled tumor protein (TCTP) domain signature 2

PROSITE patterns entry
Member databasePROSITE patterns
PROSITE patterns typeconserved site
Short nameTCTP_2

Description

The translationally controlled tumor proteins (TCTPs, such as p21, p23 and histamine releasing factor (HRF)) are a highly conserved and abundantly expressed family of eukaryotic proteins that are implicated in a variety of cellular functions, including microtubule stabilization, cell cycle, apoptosis, and cytokine release. TCTP is ubiquitously expressed in all eukaryotic organisms from protozoa such as Plasmodium sp. to plants and mammals
[1]
[2]
[4]
[3]
. The TCTP domain structure comprises four beta-sheets, designated A-D, and three main helices, designated H1-H3, connected in a complex topology. A central feature of the structure is the four-stranded sheet A, against one face of which packs the three-stranded sheet B and the small helix H1. Helix H3 packs against part of the opposite face of sheet A. Helix H2 packs against helix H3 (forming an alpha-helical hairpin). The final major structural feature is the two-stranded sheet C, which protrudes from the core globular structure formed by the rest of the domain
[1]
. As signature patterns for the TCTP domain, we selected two of the best conserved regions. We also developed a profile that covers the entire TCTP domain.

References

1.Structure of TCTP reveals unexpected relationship with guanine nucleotide-free chaperones. Thaw P, Baxter NJ, Hounslow AM, Price C, Waltho JP, Craven CJ. Nat. Struct. Biol. 8, 701-4, (2001). View articlePMID: 11473261

2.To cease or to proliferate: new insights into TCTP function from a Drosophila study. Choi KW, Hsu YC. Cell Adh Migr 1, 129-30, (2007). View articlePMID: 19262129

3.Molecular interaction of artemisinin with translationally controlled tumor protein (TCTP) of Plasmodium falciparum. Eichhorn T, Winter D, Buchele B, Dirdjaja N, Frank M, Lehmann WD, Mertens R, Krauth-Siegel RL, Simmet T, Granzin J, Efferth T. Biochem. Pharmacol. 85, 38-45, (2013). View articlePMID: 23085438

4.TCTP protects from apoptotic cell death by antagonizing bax function. Susini L, Besse S, Duflaut D, Lespagnol A, Beekman C, Fiucci G, Atkinson AR, Busso D, Poussin P, Marine JC, Martinou JC, Cavarelli J, Moras D, Amson R, Telerman A. Cell Death Differ. 15, 1211-20, (2008). View articlePMID: 18274553

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