Member database | PROSITE patterns |
PROSITE patterns type | conserved site |
Short name | STATHMIN_2 |
Description
Stathmin
[1] (from the Greek 'stathmos' which means relay), is an ubiquitous
intracellular protein, present in a variety of phosphorylated forms and which
is involved in the regulation of the microtubule (MT) filament system by
destabilizing microtubules. It prevents assembly and promotes disassembly of
microtubules.
Stathmin belongs to a family that also includes:
- Stathmin 2 (Protein SCG10); a neuron-specific, membrane-associated protein
that accumulates in the growth cones of developing neurons. It is highly
similar in its sequence to stathmin, but differs in that it contains an
additional N-terminal hydrophobic segment of 32 residues which is probably
responsible for its interaction with membranes.
- Stathmin 3 (SCG10-like protein; SCLIP)
[4]; a protein specifically
expressed in neurons.
- Stathmin 4 (Stathmin-like protein B3); which contains an additional N-
terminal hydrophobic domain
[3].
These proteins possess a stathmin-like domain (SLD) with various N-terminal
extensions. SLD is a highly conserved domain of 149 amino acid residues.
Structurally, it consists of an N-terminal domain of about 45 residues
followed by a 78 residue alpha-helical domain consisting of a heptad repeat
coiled coil structure and a C-terminal domain of 25 residues
[2]. The SLD binds two tubulins arranged longitudinally, head-to-tail, in
protofilament-like complexes.
As signatures for proteins of the stathmin family, we selected a conserved
decapeptide which ends with the first three residues of the coiled coil
domain and a second pattern that corresponds to part of the central region of
the coiled coil. We also developed a profile that covers the entire SLD
domain.
References
1.Stathmin: a relay phosphoprotein for multiple signal transduction? Sobel A. Trends Biochem. Sci. 16, 301-5, (1991). View articlePMID: 1957351
2.Insight into tubulin regulation from a complex with colchicine and a stathmin-like domain. Ravelli RB, Gigant B, Curmi PA, Jourdain I, Lachkar S, Sobel A, Knossow M. Nature 428, 198-202, (2004). View articlePMID: 15014504
3.The stathmin family -- molecular and biological characterization of novel mammalian proteins expressed in the nervous system. Ozon S, Maucuer A, Sobel A. Eur. J. Biochem. 248, 794-806, (1997). View articlePMID: 9342231