PS01166

RNA polymerases beta chain signature

PROSITE patterns entry
Member databasePROSITE patterns
PROSITE patterns typeconserved site
Short nameRNA_POL_BETA

Description

DNA-dependent RNA polymerases (EC 2.7.7.6) are ubiquitous enzymes necessary for the transcription of genomic DNA into RNA. Most RNA polymerases are multimeric enzymes and are composed of a variable number of subunits. However the two largest subunits (generally known as alpha and beta chains) are present in all known multimeric RNA polymerases. The beta chain is currently known in: - Eubacterial RNA polymerase beta chain (gene rpoB). - Plants and algal chloroplast RNA polymerase beta chain (gene rpoB). - Eukaryotes RNA polymerases I, II and III second largest subunits. - Archebacterial RNA polymerase subunit B (gene rpoB) or B' (gene rpoB1). - Poxviruses RNA polymerase 132 Kd subunit (gene RPO132). - Baculoviruses RNA polymerase subunit LEF-8. - African swine fever virus RNA polymerase subunit EP1242L. - Fungal plasmid-encoded RNA polymerases. The beta chains are proteins of from 900 to 1400 amino acid residues. A well conserved region of 13 residues that contains two conserved lysines and which is thought to be part of the active site is located in the C-terminal part of all beta chains
[1]
. We have used this region as a signature pattern.

References

1.A baculovirus gene involved in late gene expression predicts a large polypeptide with a conserved motif of RNA polymerases. Passarelli AL, Todd JW, Miller LK. J. Virol. 68, 4673-8, (1994). View articlePMID: 8207843

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