Member database | PROSITE patterns |
PROSITE patterns type | conserved site |
Short name | RNA_POL_BETA |
Description
DNA-dependent RNA polymerases (EC 2.7.7.6) are ubiquitous enzymes necessary
for the transcription of genomic DNA into RNA. Most RNA polymerases are
multimeric enzymes and are composed of a variable number of subunits. However
the two largest subunits (generally known as alpha and beta chains) are
present in all known multimeric RNA polymerases. The beta chain is currently
known in:
- Eubacterial RNA polymerase beta chain (gene rpoB).
- Plants and algal chloroplast RNA polymerase beta chain (gene rpoB).
- Eukaryotes RNA polymerases I, II and III second largest subunits.
- Archebacterial RNA polymerase subunit B (gene rpoB) or B' (gene rpoB1).
- Poxviruses RNA polymerase 132 Kd subunit (gene RPO132).
- Baculoviruses RNA polymerase subunit LEF-8.
- African swine fever virus RNA polymerase subunit EP1242L.
- Fungal plasmid-encoded RNA polymerases.
The beta chains are proteins of from 900 to 1400 amino acid residues. A well
conserved region of 13 residues that contains two conserved lysines and which
is thought to be part of the active site is located in the C-terminal part of
all beta chains
[1]. We have used this region as a signature pattern.
References
1.A baculovirus gene involved in late gene expression predicts a large polypeptide with a conserved motif of RNA polymerases. Passarelli AL, Todd JW, Miller LK. J. Virol. 68, 4673-8, (1994). View articlePMID: 8207843