PS01295

4-diphosphocytidyl-2C-methyl-D-erythritol synthase signature

PROSITE patterns entry
Member databasePROSITE patterns
PROSITE patterns typeconserved site
Short nameISPD

Description

The bacterial ispD protein
[1]
catalyzes the third step of the deoxyxylulose- 5-phosphate pathway (DXP) of isoprenoid biosynthesis; the formation of 4- diphosphocytidyl-2C-methyl-D-erythritol from CTP and 2C-methyl-D-erythritol 4-phosphate. These proteins can be picked up in the database by a pattern centered on a central conserved region that contains a conserved Asp and Arg residues.

References

1.Cytidine 5'-triphosphate-dependent biosynthesis of isoprenoids: YgbP protein of Escherichia coli catalyzes the formation of 4-diphosphocytidyl-2-C-methylerythritol. Rohdich F, Wungsintaweekul J, Fellermeier M, Sagner S, Herz S, Kis K, Eisenreich W, Bacher A, Zenk MH. Proc. Natl. Acad. Sci. U.S.A. 96, 11758-63, (1999). View articlePMID: 10518523

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