PS01355

Short hematopoietin receptor family 1 signature

PROSITE patterns entry
Member databasePROSITE patterns
PROSITE patterns typeconserved site
Short nameHEMATOPO_REC_S_F1

Description

A number of receptors for lymphokines, hematopoietic growth factors and growth hormone-related molecules have been found to share a common binding domain. These receptors are designated as hematopoietin receptors
[2]
and the corresponding ligands as hematopoietins. Further, hematopoietins have been subdivided into two major structural groups: Large/long and small/short hematopoietins. One subset of individual receptor chains that are part of receptor complexes for small hematopoietins are structurally related such that their extracellular parts strictly contain the 200 amino-acids hematopoietin domain (duplicated in IL-3/-5/GM-CSF beta chain receptors KH97/AIC2B and AIC2A). They define a structural subgroup containing the following chains: - Interleukin-2 receptor beta chain (IL2RB) - Interleukin-2 receptor common gamma chain (IL2RG) - Interleukin-3 receptor beta chain (AIC2A) - Interleukin-3/-5/GM-CSF receptor common beta chain (KH97/AIC2B) - Interleukin-4 receptor alpha chain (IL4RA) - Interleukin-7 receptor alpha chain (IL7RA) - Interleukin-9 receptor alpha chain (IL9RA) A schematic representation of the structure of these receptors is shown below: +----------------------------------------xxxxxxx---------------------------+ | C C C C Extracellular XXXXXXX Cytoplasmic | +-|-|-------|--|-------------------------xxxxxxx---------------------------+ | | | | Transmembrane +-+ +--+ IL4RA, IL7RA and IL9RA are specific alpha chain receptors for IL-4, IL-7 and IL-9 respectively, whereas IL2RB is common to IL-2 and IL-15 (IL2RA and IL15RA are not members of the hematopoietin receptor superfamily). IL2RG is part of IL-2, IL-15, IL-7, IL-9 and IL-4 form I receptor complexes
[1]
. KH97/AIC2B chain is part of GM-CSF, IL-3 and IL-5 receptor complexes and in the mouse, AIC2B can be substituted by AIC2A, an IL-3 specific beta chain receptor
[3]
. Together with either IL13RA1 or IL13RA2, IL4RA is also part of the IL-13 receptor complex for which IL-4 can compete with IL-13 (IL-4 receptor complex form II)
[4]
. We have used one pattern to detect this subfamily. The motif is located at the carboxy-terminal part of the 200 amino acid hematopoietin domain.

References

1.The defective gene in X-linked severe combined immunodeficiency encodes a shared interleukin receptor subunit: implications for cytokine pleiotropy and redundancy. Leonard WJ. Curr. Opin. Immunol. 6, 631-5, (1994). View articlePMID: 7946053

2.Hematopoietin sub-family classification based on size, gene organization and sequence homology. Boulay JL, Paul WE. Curr. Biol. 3, 573-81, (1993). View articlePMID: 15335670

3.Subunit promiscuity among hemopoietic growth factor receptors. Nicola NA, Metcalf D. Cell 67, 1-4, (1991). View articlePMID: 1913811

4.Cloning and characterization of a binding subunit of the interleukin 13 receptor that is also a component of the interleukin 4 receptor. Hilton DJ, Zhang JG, Metcalf D, Alexander WS, Nicola NA, Willson TA. Proc. Natl. Acad. Sci. U.S.A. 93, 497-501, (1996). View articlePMID: 8552669

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