PS01356

Short hematopoietin receptor family 2 signature

PROSITE patterns entry
Member databasePROSITE patterns
PROSITE patterns typeconserved site
Short nameHEMATOPO_REC_S_F2

Description

A number of receptors for lymphokines, hematopoietic growth factors and growth hormone-related molecules have been found to share a common binding domain. These receptors are designated as hematopoietin receptors
[2]
and the corresponding ligands as hematopoietins. Further, hematopoietins have been subdivided into two major structural groups: Large/long and small/short hematopoietins. One subset of individual receptor chains that are part of receptor complexes for small hematopoietins contain common structural elements in their extracellular parts: an immunoglobulin-like domain at the N-terminal end of the hematopoietin receptor domain and a rather short cytoplasmic domain. They define a structural subgroup containing the following chains: - Granulocyte/macrophage colony stimulating factor receptor alpha (GMCSFRA). - Interleukin-3 receptor alpha chain (IL3RA). - Interleukin-5 receptor alpha chain (IL5RA). - Interleukin-13 receptor alpha-1 chain (IL13RA1). - Interleukin-13 receptor alpha-2 chain (IL13RA2). A schematic representation of the structure of these receptors is shown below: +-----------+-------------------------------------------xxxxxxx-------------+ | Ig-like | C C C C Extracellular XXXXXXX Cytoplasmic | +-----------+--|-|-----|--|-----------------------------xxxxxxx-------------+ | | | | Transmembrane +-+ +--+ GMCSFRA, IL3RA or IL5RA chains of this subgroup bind to their cognate cytokines: GM-CSF, IL-3 and IL-5, with a common beta chain, KH97/AIC2B
[1]
. Either IL13RA1 chain or IL13RA2 chain form the IL13R complex together with IL4RA chain. IL-4 can compete with IL-13 to bind to either IL13R form
[3]
. We have used one pattern to detect this subfamily. The motif is located a the N-terminal end of the 200 amino acid hematopoietin domain.

References

1.Subunit promiscuity among hemopoietic growth factor receptors. Nicola NA, Metcalf D. Cell 67, 1-4, (1991). View articlePMID: 1913811

2.Hematopoietin sub-family classification based on size, gene organization and sequence homology. Boulay JL, Paul WE. Curr. Biol. 3, 573-81, (1993). View articlePMID: 15335670

3.Cloning and characterization of a binding subunit of the interleukin 13 receptor that is also a component of the interleukin 4 receptor. Hilton DJ, Zhang JG, Metcalf D, Alexander WS, Nicola NA, Willson TA. Proc. Natl. Acad. Sci. U.S.A. 93, 497-501, (1996). View articlePMID: 8552669

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