Member database | PROSITE patterns |
PROSITE patterns type | conserved site |
Short name | HEMATOPO_REC_S_F2 |
Description
A number of receptors for lymphokines, hematopoietic growth factors and
growth hormone-related molecules have been found to share a common binding
domain. These receptors are designated as hematopoietin receptors
[2] and
the corresponding ligands as hematopoietins. Further, hematopoietins have been
subdivided into two major structural groups: Large/long and small/short
hematopoietins.
One subset of individual receptor chains that are part of receptor complexes
for small hematopoietins contain common structural elements in their
extracellular parts: an immunoglobulin-like domain at the N-terminal end of
the hematopoietin receptor domain and a rather short cytoplasmic domain. They
define a structural subgroup containing the following chains:
- Granulocyte/macrophage colony stimulating factor receptor alpha (GMCSFRA).
- Interleukin-3 receptor alpha chain (IL3RA).
- Interleukin-5 receptor alpha chain (IL5RA).
- Interleukin-13 receptor alpha-1 chain (IL13RA1).
- Interleukin-13 receptor alpha-2 chain (IL13RA2).
A schematic representation of the structure of these receptors is shown below:
+-----------+-------------------------------------------xxxxxxx-------------+
| Ig-like | C C C C Extracellular XXXXXXX Cytoplasmic |
+-----------+--|-|-----|--|-----------------------------xxxxxxx-------------+
| | | | Transmembrane
+-+ +--+
GMCSFRA, IL3RA or IL5RA chains of this subgroup bind to their cognate
cytokines: GM-CSF, IL-3 and IL-5, with a common beta chain, KH97/AIC2B
[1].
Either IL13RA1 chain or IL13RA2 chain form the IL13R complex together with
IL4RA chain. IL-4 can compete with IL-13 to bind to either IL13R form
[3].
We have used one pattern to detect this subfamily. The motif is located a
the N-terminal end of the 200 amino acid hematopoietin domain.
References
1.Subunit promiscuity among hemopoietic growth factor receptors. Nicola NA, Metcalf D. Cell 67, 1-4, (1991). View articlePMID: 1913811
2.Hematopoietin sub-family classification based on size, gene organization and sequence homology. Boulay JL, Paul WE. Curr. Biol. 3, 573-81, (1993). View articlePMID: 15335670
3.Cloning and characterization of a binding subunit of the interleukin 13 receptor that is also a component of the interleukin 4 receptor. Hilton DJ, Zhang JG, Metcalf D, Alexander WS, Nicola NA, Willson TA. Proc. Natl. Acad. Sci. U.S.A. 93, 497-501, (1996). View articlePMID: 8552669