SFLDF00294

7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase (CofG-like)

SFLD entry
Member databaseSFLD
SFLD typefamily
Short name7_8-didemethyl-8-hydroxy-5-dea

Description

This subunit performs the second half reaction of FO synthase, the rearrangement of 5-amino-5-(4-hydroxybenzyl)-6-((2,3,4,5-tetrahydroxypentyl)amino)dihydropyrimidine-2,4(1H,3H)-dione to form 7,8-didemethyl-8-hydroxy-5-deazariboflavin and ammonia
[2, 1, 3, 4]
. RXN 1chebi:85512+1chebi:59789<=>1chebi:59904+1chebi:17319+1chebi:57844

References

1.Critical role of 7,8-didemethyl-8-hydroxy-5-deazariboflavin for photoreactivation in Chlamydomonas reinhardtii. Petersen JL, Ronan PJ. J. Biol. Chem. 285, 32467-75, (2010). View articlePMID: 20696762

2.Identification of the 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase required for coenzyme F(420) biosynthesis. Graham DE, Xu H, White RH. Arch. Microbiol. 180, 455-64, (2003). View articlePMID: 14593448

3.Biosynthesis of F0, precursor of the F420 cofactor, requires a unique two radical-SAM domain enzyme and tyrosine as substrate. Decamps L, Philmus B, Benjdia A, White R, Begley TP, Berteau O. J Am Chem Soc 134, 18173-6, (2012). PMID: 23072415

4.Biosynthetic versatility and coordinated action of 5'-deoxyadenosyl radicals in deazaflavin biosynthesis. Philmus B, Decamps L, Berteau O, Begley TP. J. Am. Chem. Soc. 137, 5406-13, (2015). View articlePMID: 25781338

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