SFLDF00299

anaerobic ribonucleoside-triphosphate reductase activase

SFLD entry
Member databaseSFLD
SFLD typefamily
Short nameanaerobic_ribonucleoside-triph

Description

This family of proteins are members of the radical SAM superfamily and utilise S-adenosyl methionine, an iron-sulphur cluster and a reductant (dihydroflavodoxin) to produce a glycine-centred radical in the class III (anaerobic) ribonucleotide triphosphate reductase
[1, 3, 2]
. RXN 1pdb:4coi+1chebi:67040+1chebi:62787<=>1pdb:4coi+1chebi:57844+1chebi:17319+1chebi:15817

References

1.Activation of class III ribonucleotide reductase from E. coli. The electron transfer from the iron-sulfur center to S-adenosylmethionine. Padovani D, Thomas F, Trautwein AX, Mulliez E, Fontecave M. Biochemistry 40, 6713-9, (2001). View articlePMID: 11389585

2.The anaerobic ribonucleotide reductase from Lactococcus lactis. Interactions between the two proteins NrdD and NrdG. Torrents E, Eliasson R, Wolpher H, Graslund A, Reichard P. J. Biol. Chem. 276, 33488-94, (2001). View articlePMID: 11427536

3.Activation of class III ribonucleotide reductase by flavodoxin: a protein radical-driven electron transfer to the iron-sulfur center. Mulliez E, Padovani D, Atta M, Alcouffe C, Fontecave M. Biochemistry 40, 3730-6, (2001). View articlePMID: 11297442

Integrated to
External Links
This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our Privacy Notice and Terms of Use.