Member database | SFLD |
SFLD type | family |
Short name | PLP-dependent |
Description
All the proteins in this subgroup appear to be PLP-dependent and are thought to carry out B12-like rearrangements. Whilst the best chcracterised of this set are the lysine 2,3-aminomutases, it is currently unclear if all the enzymes in this set are aminomutases. They all bind SAM via the canonical CxxxCxxC motif. The putative families in this subgroup have been determined by using an E() Value cut-off of 1E-75
[2, 1].
RXN 1chebi:32551<=>1chebi:57434
RXN 1chebi:29985<=>1chebi:66948
RXN 1chebi:32682<=>1chebi:85624
References
1.Glutamate 2,3-aminomutase: a new member of the radical SAM superfamily of enzymes. Ruzicka FJ, Frey PA. Biochim. Biophys. Acta 1774, 286-96, (2007). View articlePMID: 17222594
2.The x-ray crystal structure of lysine-2,3-aminomutase from Clostridium subterminale. Lepore BW, Ruzicka FJ, Frey PA, Ringe D. Proc. Natl. Acad. Sci. U.S.A. 102, 13819-24, (2005). View articlePMID: 16166264