SFLDG01070

PLP-dependent

SFLD entry
Member databaseSFLD
SFLD typefamily
Short namePLP-dependent

Description

All the proteins in this subgroup appear to be PLP-dependent and are thought to carry out B12-like rearrangements. Whilst the best chcracterised of this set are the lysine 2,3-aminomutases, it is currently unclear if all the enzymes in this set are aminomutases. They all bind SAM via the canonical CxxxCxxC motif. The putative families in this subgroup have been determined by using an E() Value cut-off of 1E-75
[2, 1]
. RXN 1chebi:32551<=>1chebi:57434 RXN 1chebi:29985<=>1chebi:66948 RXN 1chebi:32682<=>1chebi:85624

References

1.Glutamate 2,3-aminomutase: a new member of the radical SAM superfamily of enzymes. Ruzicka FJ, Frey PA. Biochim. Biophys. Acta 1774, 286-96, (2007). View articlePMID: 17222594

2.The x-ray crystal structure of lysine-2,3-aminomutase from Clostridium subterminale. Lepore BW, Ruzicka FJ, Frey PA, Ringe D. Proc. Natl. Acad. Sci. U.S.A. 102, 13819-24, (2005). View articlePMID: 16166264

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